
sulfadiazine oral brand names and other generic formulations include:
Microsulfon Oral
warfarin iv brand names and other generic formulations include:
Coumadin IV
sulfadiazine oral and warfarin iv
sulfadiazine oral will increase the level or effect of warfarin iv by altering drug metabolism.
sulfadiazine oral and warfarin iv
sulfadiazine oral will increase the level or effect of warfarin iv by affecting hepatic enzyme CYP2C9/10 metabolism. Mechanism of interaction may be caused by CYP2C9 inhibition and protein-binding displacement. If coadministered, consider decreasing warfarin dose by 10-20%.
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant