
topiramate oral brand names and other generic formulations include:
Qudexy XR Oral, Topamax Oral, Topiragen Oral, Trokendi XR Oral
pioglitazone-metformin oral brand names and other generic formulations include:
Actoplus MET Oral, Actoplus Met XR Oral
topiramate oral and pioglitazone-metformin oral
topiramate oral increases toxicity of pioglitazone-metformin oral by Other mechanism. This combination increases the risk of increased blood acidity.
topiramate oral and pioglitazone-metformin oral
topiramate oral increases toxicity of pioglitazone-metformin oral by Other (see comment). Decreases serum bicarbonate and induce non-anion gap, hyperchloremic metabolic acidosis
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant