
vorinostat oral brand names and other generic formulations include:
valproate sodium iv brand names and other generic formulations include:
vorinostat oral and valproate sodium iv
vorinostat oral , valproate sodium iv added drug effects. Combination increases the risk of low platelets and bleeding from the stomach and intestines.
vorinostat oral and valproate sodium iv
vorinostat oral , valproate sodium iv pharmacodynamic synergism. Risk of severe thrombocytopenia and GI bleeding. Monitor platelet count q 2 wks for first 2 months.
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant