Drug interactions with zileuton oral and sonidegib oral

zileuton oral brand names and other generic formulations include:

Zyflo CR Oral, Zyflo Oral

All generic drug interactions for zileuton oral (lists will include brand and generic names):

sonidegib oral brand names and other generic formulations include:

Odomzo Oral

All generic drug interactions for sonidegib oral (lists will include brand and generic names):
Monitor CloselyPotential for significant interaction (monitoring by your doctor is likely required)

zileuton oral and sonidegib oral

zileuton oral will increase the level or effect of sonidegib oral by altering drug metabolism. Avoid this combination. If sonidegib must be combined with this drug give the interacting drug for less than 14 days and monitor closely for adverse reactions, particularly musculoskeletal adverse reactions.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyModify Therapy/Monitor Closely.

zileuton oral and sonidegib oral

zileuton oral will increase the level or effect of sonidegib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of sonidegib with moderate CYP3A4 inhibitors. If a moderate CYP3A inhibitor must be used, administer the moderate CYP3A inhibitor for <14 days and monitor closely for adverse reactions, particularly musculoskeletal adverse reactions.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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