zileuton oral brand names and other generic formulations include:
tofacitinib oral brand names and other generic formulations include:
zileuton oral and tofacitinib oral
zileuton oral increases levels of tofacitinib oral by altering drug metabolism. Blood levels of tofacitinib may be affected but there is no recommended dose adjustment.
zileuton oral and tofacitinib oral
zileuton oral increases levels of tofacitinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. No specific dose adjustment recommended when tofacitinib coadministered with moderate CYP3A4 inhibitors; decrease tofacitinib dose if coadministered with both moderate CYP3A4 and potent CYP2C19 inhibitors
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant