zileuton oral brand names and other generic formulations include:
warfarin iv brand names and other generic formulations include:
Coumadin IV
zileuton oral and warfarin iv
zileuton oral will increase the level or effect of warfarin iv by Other mechanism.
zileuton oral and warfarin iv
zileuton oral will increase the level or effect of warfarin iv by Other (see comment). Warfarin's less potent R-enantiomer is metabolized in part by CYP3A4 (and also CYP1A2 and CYP2C19). Monitor INR more frequently if coadministered with inhibitors of these isoenzymes and adjust warfarin dose if needed.
Check for more interactions with the Drug Interaction Checker
Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant