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Duac

Last reviewed on RxList: 2/8/2017
Duac Side Effects Center

Last reviewed on RxList 01/26/2017

Duac (clindamycin phosphate and benzoyl peroxide) Gel is a combination of an antibiotic and an antibacterial that also has a mild drying effect used to treat acne. Common side effects of Duac Gel include dry skin, redness, burning, itching, stinging, tingly feeling, redness or other irritation, or skin peeling. Tell your doctor if you have serious side effects of Duac Gel including:

  • severe redness,
  • burning,
  • stinging, or
  • peeling of treated skin areas; or
  • diarrhea that is watery or bloody.

Duac Gel topical (for the skin) is applied in a once daily dose as directed by a physician to affected areas after the skin is gently washed, rinsed with warm water and patted dry. Duac may interact with topical or oral erythromycin. Other drugs may interact with Duac. Tell your doctor about all the prescription and over-the-counter medications and supplements you use. During pregnancy, Duac should be used only when prescribed. This drug may pass into breast milk and could have undesirable effects on a nursing infant. Consult your doctor before breastfeeding.

Our Duac (clindamycin phosphate and benzoyl peroxide) Gel Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Duac Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have any of these serious side effects:

  • severe redness, burning, stinging, or peeling of treated skin areas; or
  • diarrhea that is watery or bloody.

Less serious side effects may include:

  • mild burning or stinging;
  • itching or tingly feeling;
  • dryness or peeling of treated skin; or
  • redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Duac (Clindamycin Benzoyl Peroxide)

Duac Professional Information

SIDE EFFECTS

The following adverse reaction is described in more detail in the WARNINGS AND PRECAUTIONS section of the label:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

During clinical trials, 397 subjects used DUAC Gel once daily for 11 weeks for the treatment of moderate to moderately severe facial acne vulgaris. All subjects were graded for facial local skin reactions (erythema, peeling, burning, and dryness) on the following scale: 0 = absent, 1 = mild, 2 = moderate, and 3 = severe. The percentage of subjects that had symptoms present before treatment (at baseline) and during treatment is presented in Table 1.

Table 1: Local Skin Reactions With Use of DUAC Gel Combined Results From Five Trials (n = 397)

Symptom % of Subjects Using DUAC Gel With Symptom Present
Before Treatment (Baseline) During Treatment
Mild Moderate Severe Mild Moderate Severe
Erythema 28% 3% 0 26% 5% 0
Peeling 6% < 1% 0 17% 2% 0
Burning 3% < 1% 0 5% < 1% 0
Dryness 6% < 1% 0 15% 1% 0
(Percentages derived by number of subjects receiving DUAC Gel with symptom score/number of enrolled subjects receiving DUAC Gel).

Postmarketing Experience

The following adverse reactions have been identified during post approval use of DUAC Gel. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Anaphylaxis, as well as allergic reactions leading to hospitalization, has been reported in postmarketing use with DUAC Gel.

Read the entire FDA prescribing information for Duac (Clindamycin Benzoyl Peroxide)

Related Resources for Duac

Read the Duac User Reviews »

© Duac Patient Information is supplied by Cerner Multum, Inc. and Duac Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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