Duexis vs. Celebrex

Are Duexis and Celebrex the Same Thing?

Duexis (ibuprofen and famotidine) and Celebrex (celecoxib) are used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis.

Duexis is used when there is a high risk of developing upper gastrointestinal ulcers.

Celebrex is also used for familial FAP, acute pain, and menstrual cramps.

Both Duexis and Celebrex are nonsteroidal anti-inflammatory drugs (NSAIDs) but Duexis also contains a histamine H2-receptor antagonist.

Side effects of Duexis and Celebrex that are similar include stomach pain, upset stomach, diarrhea, bloating, gas, heartburn/indigestion, nausea, dizziness, headache, or throat irritation.

Side effects of Duexis that are different from Celebrex include constipation, vomiting, blurred vision, changes in color vision, or back pain.

Side effects of Celebrex that are different from Duexis include nervousness, headache, runny or stuffy nose, skin rash, insomnia, and serious stomach and intestinal ulcers.

Both Duexis and Celebrex may interact with blood thinners, antidepressants, or cold, allergy, or pain medicines that contain nonsteroidal anti-inflammatory drugs (NSAIDs).

Celebrex may also interact with diuretics (water pills), fluconazole, lithium, heart or blood pressure medications, or ACE inhibitors.

What Are Possible Side Effects of Duexis?

Common side effects of Duexis include:

  • stomach pain,
  • upset stomach,
  • constipation,
  • diarrhea,
  • bloating,
  • gas,
  • heartburn,
  • nausea,
  • vomiting,
  • dizziness,
  • headache,
  • throat irritation,
  • blurred vision,
  • changes in color vision, or
  • back pain.

Duexis can cause serious or fatal side effects including:

What Are Possible Side Effects of Celebrex?

Common side effects of Celebrex include:

  • headache,
  • abdominal pain,
  • indigestion,
  • diarrhea,
  • nausea,
  • upset stomach,
  • bloating,
  • gas,
  • dizziness,
  • nervousness,
  • headache,
  • runny or stuffy nose,
  • sore throat,
  • skin rash, and
  • insomnia.

Celebrex may cause serious stomach and intestinal ulcers.

What Is Duexis?

Duexis (ibuprofen and famotidine) is a combination of a nonsteroidal anti-inflammatory drug (NSAID) and a histamine H2-receptor antagonist used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers.

What Is Celebrex?

Celebrex used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as different types of arthritis, menstrual cramps, and other types of short-term pain.


The term arthritis refers to stiffness in the joints. See Answer

What Drugs Interact With Duexis?

Duexis may interact with ACE-inhibitors. Duexis contains ibuprofen and may interact with anticoagulant medication such as Warfarin (Coumadin). Tell your doctor all medications you use. Duexis should not be given to women in late stages of pregnancy. There is potential for adverse reactions in nursing infants; consult your doctor before breastfeeding.

What Drugs Interact With Celebrex?

Do not take Celebrex:

How Should Duexis Be Taken?

Duexis is dosed as 800 mg/26.6 mg tablets, taken orally, three times per day.

How Should Celebrex Be Taken?

Carefully consider the potential benefits and risks of Celebrex and other treatment options before deciding to use Celebrex. Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.


What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow

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Horizon Pharma USA, Inc. Duexis Product Information.
Pfizer. Celebrex Product Information.

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