Duexis vs. Naprosyn

Are Duexis and Naprosyn the Same Thing?

Duexis (ibuprofen and famotidine) and Naprosyn (naproxen) are used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis.

Duexis is used when there is a high risk of developing upper gastrointestinal ulcers.

Naprosyn is also used to treat inflammatory diseases such as tendonitis, bursitis, and gout.

Both Duexis and Naprosyn are nonsteroidal anti-inflammatory drugs (NSAIDs) but Duexis also contains a histamine H2-receptor antagonist.

Side effects of Duexis and Naprosyn that are similar include stomach pain, upset stomach, constipation, diarrhea, bloating, gas, heartburn, nausea, dizziness, headache, or blurred vision.

Side effects of Duexis that are different from Naprosyn include vomiting, throat irritation, changes in color vision, or back pain.

Side effects of Naprosyn that are different from Duexis include nervousness, skin rash, ringing in your ears, and itching.

Both Duexis and Naprosyn may interact with blood thinners, antidepressants, or cold, allergy, or pain medicines that contain nonsteroidal anti-inflammatory drugs (NSAIDs).

Naprosyn may also interact with lithium, methotrexate, diuretics (water pills), steroids, or heart or blood pressure medications.

What Are Possible Side Effects of Duexis?

Common side effects of Duexis include:

  • stomach pain,
  • upset stomach,
  • constipation,
  • diarrhea,
  • bloating,
  • gas,
  • heartburn,
  • nausea,
  • vomiting,
  • dizziness,
  • headache,
  • throat irritation,
  • blurred vision,
  • changes in color vision, or
  • back pain.

Duexis can cause serious or fatal side effects including:

What Are Possible Side Effects of Naprosyn?

Common side effects of Naprosyn include:

  • heartburn,
  • stomach or abdominal pain,
  • upset stomach,
  • nausea,
  • diarrhea,
  • constipation,
  • bloating,
  • gas,
  • dizziness,
  • nervousness,
  • skin rash,
  • headache,
  • blurred vision,
  • ringing in your ears, and
  • itching.

What Is Duexis?

Duexis (ibuprofen and famotidine) is a combination of a nonsteroidal anti-inflammatory drug (NSAID) and a histamine H2-receptor antagonist used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers.

What Is Naprosyn?

Naprosyn (naproxen; other brand names: EC-Naprosyn and Anaprox/Anaprox DS), is a proprionic acid derivative and is considered a nonsteroidal anti-inflammatory drug (NSAID) and is used for pain management for many diseases, arthritic diseases, and inflammatory diseases such as tendonitis, bursitis, and gout.


What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow

What Drugs Interact With Duexis?

Duexis may interact with ACE-inhibitors. Duexis contains ibuprofen and may interact with anticoagulant medication such as Warfarin (Coumadin). Tell your doctor all medications you use. Duexis should not be given to women in late stages of pregnancy. There is potential for adverse reactions in nursing infants; consult your doctor before breastfeeding.

What Drugs Interact With Naprosyn?

Naprosyn may interact with aspirin, blood thinners, lithium, methotrexate, heart or blood pressure medications, diuretics (water pills), or steroids.

Avoid taking Naprosyn after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

How Should Duexis Be Taken?

Duexis is dosed as 800 mg/26.6 mg tablets, taken orally, three times per day.

How Should Naprosyn Be Taken?

Naprosyn is available in several doses and drug configurations; Naprosyn tablets with strengths of 250, 375 and 500 mg and as an oral suspension containing 125 mg Naprosyn per 5 ml of liquid, EC-Naprosyn (delayed release to reduce gastric irritation) with strengths of 375 and 500 mg, Anaprox in 275 mg tablets, Anaprox DS in 550 mg tablets. Almost all Naprosyn drugs are recommended to be dosed twice per day (every 12 hours) with children's doses (strength in mg per Kg) based on the child's weight, also twice a day with a maximum dose of 15 mg per Kg per day.


The term arthritis refers to stiffness in the joints. See Answer

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Horizon Pharma USA, Inc. Duexis Product Information.
Dailymed. Naprosyn Product Information.

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