Duexis vs. Vimovo

Are Duexis and Vimovo the Same Thing?

Duexis (ibuprofen and famotidine) and Vimovo (naproxen and esomeprazole magnesium) are combination drugs used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing gastrointestinal ulcers.

Both Duexis and Vimovo contain a nonsteroidal anti-inflammatory drug (NSAID). The difference is Duexis also contains a histamine H2-receptor antagonist while Vimovo contains a proton pump inhibitor (PPI).

What Are Possible Side Effects of Duexis?

Common side effects of Duexis include:

Duexis can cause serious or fatal side effects including:

What Are Possible Side Effects of Vimovo?

Common side effects of Vimovo include:

  • upset stomach,
  • stomach pain,
  • heartburn,
  • nausea,
  • gas,
  • diarrhea,
  • constipation,
  • drowsiness, or
  • dizziness.

Tell your doctor if you have serious side effects of Vimovo including:

What is Duexis?

Duexis (ibuprofen and famotidine) is a combination of a nonsteroidal anti-inflammatory drug (NSAID) and a histamine H2-receptor antagonist used to treat signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal ulcers.

What is Vimovo?

Vimovo (naproxen and esomeprazole magnesium) is a combination of a nonsteroidal anti-inflammatory drug (NSAID) and a proton pump inhibitor (PPI) used to treat signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis when there is a high risk for stomach bleeding/ulcer.


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What Drugs Interact With Duexis?

Duexis may interact with ACE-inhibitors. Duexis contains ibuprofen and may interact with anticoagulant medication such as Warfarin (Coumadin). Tell your doctor all medications you use. Duexis should not be given to women in late stages of pregnancy. There is potential for adverse reactions in nursing infants; consult your doctor before breastfeeding.

What Drugs Interact With Vimovo?

Vimovo may interact with amphetamines, oral bisphosphonates, blood thinners, anti-platelet drugs, SSRI/SNRI antidepressants, clopidogrel, corticosteroids, HIV drugs, lithium, probenecid, digoxin, azole antifungals, iron supplements, other products containing naproxen, other proton pump inhibitors. Check medicine labels as many contain pain relievers/fever reducers similar to Vimovo and may increase the risk of side effects if taken together. Tell your doctor all medications and supplements you are taking.

How Should Duexis Be Taken?

Duexis is dosed as 800 mg/26.6 mg tablets, taken orally, three times per day.

How Should Vimovo Be Taken?

The dosage of Vimovo is one tablet twice daily, 375 mg naproxen/20 mg esomeprazole or 500 mg naproxen/20 mg esomeprazole.


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Horizon Pharma USA, Inc. Duexis Product Information.
Horizon Pharma USA, Inc. Vimovo Product Information.

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