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Duoneb

Last reviewed on RxList: 9/11/2018
Duoneb Side Effects Center

Last reviewed on RxList 9/11/2018

DuoNeb (ipratropium bromide and albuterol sulfate) is a combination of bronchodilators used to treat and prevent symptoms (wheezing and shortness of breath) caused by ongoing lung disease (chronic obstructive pulmonary disease-COPD which includes bronchitis and emphysema). Common side effects of DuoNeb include:

Tell your doctor if you have serious side effects of DuoNeb including:

The recommended dose of DuoNeb is one 3 mL vial administered 4 times per day via nebulization with up to 2 additional 3 mL doses allowed per day, if needed. DuoNeb may interact with certain beta-blockers, such as propranolol. Drug interactions may change how your medications work or increase your risk for serious side effects. Tell your doctor all the products you use, including prescription/nonprescription drugs and herbal products. Do not start, stop, or change the dosage of any medicines without your doctor's approval. During pregnancy, DuoNeb should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Our DuoNeb (ipratropium bromide and albuterol sulfate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Duoneb Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • wheezing, choking, or other breathing problems after using this medicine;
  • chest pain;
  • fast or pounding heartbeats, fluttering in your chest;
  • tremors, nervousness;
  • swelling of your ankles or feet;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • painful or difficult urination; or
  • low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.

Common side effects may include:

  • headache;
  • trouble breathing; or
  • cold symptoms such as stuffy nose, sneezing, cough, or sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Duoneb (Ipratropium Bromide and Albuterol Sulfate)

Duoneb Professional Information

SIDE EFFECTS

Adverse reaction information concerning DuoNeb (ipratropium bromide and albuterol sulfate) was derived from the 12-week controlled clinical trial.

ADVERSE EVENTS OCCURRING IN ≥ 1% OF ≥ 1 TREATMENT GROUP(S) AND WHERE THE COMBINATION TREATMENT SHOWED THE HIGHEST PERCENTAGE

Body System COSTART Term Albuterol
n (%)
Ipratropium
n (%)
DuoNeb
n (%)
NUMBER OF PATIENTS 761 754 765
N (%) Patients with AE 327 (43.0) 329 (43.6) 367 (48.0)
BODY AS A W HOLE
  Pain 8 (1.1) 4 (0.5) 10 (1.3)
  Pain chest 11 (1.4) 14 (1.9) 20 (2.6)
DIGESTIVE
  Diarrhea 5 (0.7) 9 (1.2) 14 (1.8)
  Dyspepsia 7 (0.9) 8 (1.1) 10 (1.3)
  Nausea 7 (0.9) 6 (0.8) 11 (1.4)
MUSCULO-SKELETAL
  Cramps leg 8 (1.1) 6 (0.8) 11 (1.4)
RESPIRATORY
  Bronchitis 11 (1.4) 13 (1.7) 13 (1.7)
  Lung Disease 36 (4.7) 34 (4.5) 49 (6.4)
  Pharyngitis 27 (3.5) 27 (3.6) 34 (4.4)
  Pneumonia 7 (0.9) 8 (1.1) 10 (1.3)
UROGENITAL
  Infection urinary tract 3 (0.4) 9 (1.2) 12 (1.6)

Additional adverse reactions reported in more than 1% of patients treated with DuoNeb (ipratropium bromide and albuterol sulfate) included constipation and voice alterations.

In the clinical trial, there was a 0.3% incidence of possible allergic-type reactions, including skin rash, pruritus, and urticaria.

Additional information derived from the published literature on the use of albuterol sulfate and ipratropium bromide singly or in combination includes precipitation or worsening of narrow-angle glaucoma, acute eye pain, blurred vision, paradoxical bronchospasm, wheezing, exacerbation of COPD symptoms, drowsiness, aching, flushing, upper respiratory tract infection, palpitations, taste perversion, elevated heart rate, sinusitis, back pain, sore throat, and metabolic acidosis. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Read the entire FDA prescribing information for Duoneb (Ipratropium Bromide and Albuterol Sulfate)

Related Resources for Duoneb

Read the Duoneb User Reviews »

© Duoneb Patient Information is supplied by Cerner Multum, Inc. and Duoneb Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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