Dupixent

Last updated on RxList: 07/15/2021
Dupixent Patient Information Including Side Effects

Brand Names: Dupixent, Dupixent Pre-filled Pen

Generic Name: dupilumab

What is dupilumab (Dupixent, Dupixent Pre-filled Pen)?

Dupilumab is used to treat moderate-to-severe eczema (atopic dermatitis) that cannot be controlled with topical medicines applied to the skin. Dupilumab is used for eczema in adults and children at least 6 years old.

Dupilumab is also used together with other medications to treat moderate-to-severe asthma that is not controlled with other asthma medicines. Dupilumab is used for asthma in adults and children at least 12 years old.

Dupilumab is used only in adults to treat a condition called chronic rhinosinusitis (long-term sinus inflammation) that is associated with nasal polyps.

Dupilumab may also be used for purposes not listed in this medication guide.

What are the possible side effects of dupilumab (Dupixent, Dupixent Pre-filled Pen)?

Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching; fever, swollen glands, joint pain; feeling light-headed, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • new or worsening eye pain or discomfort;
  • vision changes;
  • watery eyes (your eyes may be more sensitive to light);
  • feeling like something is in your eye; or
  • blood vessel inflammation--fever, chest pain, trouble breathing, skin rash, numbness or prickly feeling in your arms or legs.

Common side effects may include:

  • pain, swelling, burning, or irritation where an injection was given;
  • blood vessel inflammation;
  • eye redness or itching, puffy eyelids;
  • stomach pain, nausea, vomiting;
  • sore throat;
  • tooth pain;
  • sleep problems (insomnia);
  • joint pain; or
  • cold sores or fever blisters on your lips or in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dupilumab (Dupixent, Dupixent Pre-filled Pen)?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

QUESTION

Eczema (also atopic eczema or atopic dermatitis) is a general medical term for many types of skin inflammation. See Answer
Dupixent Patient Information including How Should I Take

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What should I discuss with my healthcare provider before using dupilumab (Dupixent, Dupixent Pre-filled Pen)?

You should not use dupilumab if you are allergic to it.

Dupilumab should not be given to a child younger than 12 years old to treat asthma, or younger than 6 years old to treat eczema.

Tell your doctor if you have ever had:

  • eye problems;
  • a parasite infection (such as roundworms or tapeworms); or
  • if you are scheduled to receive any vaccine.

If you use dupilumab to treat eczema or chronic rhinosinusitis with nasal polyposis, tell your doctor if you also have asthma.

Tell your doctor if you are pregnant or breastfeeding.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of dupilumab on the baby.

How should I use dupilumab (Dupixent, Dupixent Pre-filled Pen)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Dupilumab is not a rescue medicine for asthma attacks. Use only fast-acting inhalation medicine for an attack. Seek medical attention if your breathing problems get worse quickly, or if you think your asthma medications are not working as well.

Dupilumab is injected under the skin, usually once every 2 to 4 weeks. Your first dose may be given in 2 injections.

A healthcare provider may teach you how to properly use the medication by yourself. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Do not shake the prefilled syringe or injection pen. Prepare your injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

Store this medicine in the original carton in the refrigerator. Protect from light and do not freeze.

Take a syringe or pen out of the refrigerator and let it reach room temperature for 30 to 45 minutes before injecting your dose. Leave the needle cap on until you are ready to inject your dose.

You may store a prefilled syringe or injection pen at cool room temperature for up to 14 days. Throw the medicine away if not used within 14 days. Do not put it back into the refrigerator.

Each prefilled syringe or injection pen is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe or pen only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

If you also use other medications to treat eczema or asthma, do not change your doses or stop using the other medications without your doctor's advice.

SLIDESHOW

Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases See Slideshow
Dupixent Patient Information including If I Miss a Dose

What happens if I miss a dose (Dupixent, Dupixent Pre-filled Pen)?

If you miss your injection by 7 days or less, use the missed dose as soon as you remember and then go back to your regular injection schedule.

If you are more than 7 days late for the injection:

  • For the every-other-week injection schedule: Skip the missed dose and use the medicine at your next scheduled injection time.
  • For the every-4-weeks schedule: Start a new dosing schedule on the day you use the missed injection and use your next injection 4 weeks later.

Do not use two doses at one time.

What happens if I overdose (Dupixent, Dupixent Pre-filled Pen)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using dupilumab (Dupixent, Dupixent Pre-filled Pen)?

Do not receive a "live" vaccine while using dupilumab. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

What other drugs will affect dupilumab (Dupixent, Dupixent Pre-filled Pen)?

Tell your doctor about all your other medicines, especially:

  • an oral, inhaled, or topical steroid medicine; or
  • any medicine to treat asthma.

This list is not complete. Other drugs may affect dupilumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Dupixent, Dupixent Pre-filled Pen)?

Your pharmacist can provide more information about dupilumab.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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