Last updated on RxList: 10/14/2020

What is Duramorph and how is it used?

Duramorph (morphine injection) is a narcotic pain reliever (opiate-type) used to treat severe pain. Duramorph is available in generic form.

What are side effects of Duramorph?

Common side effects of Duramorph include:

If Duramorph is injected, pain, redness, itching, or swelling at the injection site may occur. Tell your doctor if you have serious side effects of Duramorph including:

Dosage for Duramorph

The initial adult dose of Duramorph is 2 mg to 10 mg/70 kg of body weight.

What Drugs, Substances, or Supplements Interact with Duramorph?

Duramorph may interact with naltrexone, cimetidine, rifampin, certain medications for pain, alcohol, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, other narcotic pain relievers, and psychiatric medicines. Check labels on all medicines (such as cough-and-cold products) because they may contain ingredients that cause drowsiness. Tell your doctor about all medications you are taking.

Duramorph During Pregnancy and Breastfeeding

During pregnancy, Duramorph should be used only when prescribed. Infants born to mothers who have used this medication may have withdrawal symptoms such as irritability, abnormal/persistent crying, vomiting, or diarrhea. Tell your doctor if you notice these symptoms in your newborn. This drug passes into breast milk and the effect on a nursing infant is not known. Consult your doctor before breastfeeding. Duramorph may cause withdrawal symptoms (such as restlessness, watery eyes, widened pupils, sweating, runny nose) if you suddenly stop using it.

Additional Information

Our Duramorph (morphine injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Not For Use in Continuous Microinfusion Devices


Morphine is the most important alkaloid of opium and is a phenanthrene derivative. It is available as the sulfate salt, having the following structural formula:

  (morphine sulfate) Structural Formula Illustration

7,8-Didehydro-4,5-epoxy-17-methyl-(5α,6α)-morphinan-3,6-diol sulfate (2:1) (salt), pentahydrate
(C17H19NO3)2 • H2SO4 • 5H2O      Molecular Weight is 758.83

Preservative-free DURAMORPH (morphine sulfate injection, USP) is a sterile, nonpyrogenic, isobaric solution of morphine sulfate, free of antioxidants, preservatives or other potentially neurotoxic additives and is intended for intravenous, epidural or intrathecal administration as a narcotic analgesic. Each milliliter contains morphine sulfate 0.5 mg or 1 mg and sodium chloride 9 mg in Water for Injection. pH range is 2.5-6.5. Each 10 mL DOSETTE ampul of DURAMORPH (morphine injection) is intended for SINGLE USE ONLY. Discard any unused portion. DO NOT HEAT-STERILIZE.