Last updated on RxList: 7/14/2021
Durezol Side Effects Center

What Is Durezol?

Durezol (difuprednate) Ophthalmic Emulsion 0.05% ophthalmic (for the eye) is a topical anti-inflammatory corticosteroid used to treat eye swelling caused by surgery.

What Are Side Effects of Durezol?

Common side effects of Durezol Ophthalmic include:

  • temporary blurred vision,
  • headache,
  • burning/stinging/itching of your eyes,
  • dry or watery eyes,
  • feeling like something is in your eye, or
  • increased sensitivity of your eyes to light.

Use of Durezol for prolonged or repeated periods may result in a new fungal infection. Tell your doctor if you have unlikely but serious side effects of Durezol including:

  • new or increased eye pain/swelling/discharge/redness,
  • eye pain or discomfort in bright light, or
  • vision changes.

Dosage for Durezol

The dose of Durezol is one drop instilled into the conjunctival sac of the affected eye(s) 4 times daily beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period, followed by 2 times daily for a week and then a taper based on the response.

What Drugs, Substances, or Supplements Interact with Durezol?

It is not likely other drugs you take orally or inject will have an effect on Durezol ophthalmic used in the eyes. But many drugs can interact with each other. Tell your doctor all prescription and over-the-counter medications and supplements you use.

Durezol During Pregnancy or Breastfeeding

During pregnancy, Durezol should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Durezol (difuprednate ophthalmic emulsion) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Pink Eye (Conjunctivitis) Symptoms, Causes, Treatments See Slideshow
Durezol Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pain behind your eyes, sudden vision changes;
  • slow healing after your eye surgery;
  • eye pain, tunnel vision, or seeing halos around lights; or
  • signs of new eye infection, such as swelling, draining, or crusting of your eyes.

Common side effects may include:

  • eye itching or irritation;
  • blurred vision;
  • watery eyes;
  • headache;
  • feeling like something is in your eye; or
  • your eyes may be more sensitive to light.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Durezol (Difluprednate Opthalmic Emulsion)


What causes dry eyes? See Answer
Durezol Professional Information


Adverse reactions associated with ophthalmic steroids include elevated intraocular pressure, which may be associated with optic nerve damage, visual acuity and field defects; posterior subcapsular cataract formation; secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera.

Ocular Surgery

Ocular adverse reactions occurring in 5-15% of subjects in clinical studies with DUREZOL included corneal edema, ciliary and conjunctival hyperemia, eye pain, photophobia, posterior capsule opacification, anterior chamber cells, anterior chamber flare, conjunctival edema, and blepharitis. Other ocular adverse reactions occurring in 1-5% of subjects included reduced visual acuity, punctate keratitis, eye inflammation, and iritis. Ocular adverse reactions occurring in < 1% of subjects included application site discomfort or irritation, corneal pigmentation and striae, episcleritis, eye pruritis, eyelid irritation and crusting, foreign body sensation, increased lacrimation, macular edema, sclera hyperemia, and uveitis. Most of these reactions may have been the consequence of the surgical procedure.

Endogenous Anterior Uveitis

A total of 200 subjects participated in the clinical trials for endogenous anterior uveitis, of which 106 were exposed to DUREZOL. The most common adverse reactions of those exposed to DUREZOL occurring in 5-10% of subjects included blurred vision, eye irritation, eye pain, headache, increased IOP, iritis, limbal and conjunctival hyperemia, punctate keratitis, and uveitis. Adverse reactions occurring in 2-5% of subjects included anterior chamber flare, corneal edema, dry eye, iridocyclitis, photophobia, and reduced visual acuity.

Read the entire FDA prescribing information for Durezol (Difluprednate Opthalmic Emulsion)

© Durezol Patient Information is supplied by Cerner Multum, Inc. and Durezol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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