Medical Editor: John P. Cunha, DO, FACOEP
Duricef (cefadroxil) is a cephalosporin antibiotic used to treat many different types of infections caused by bacteria. The brand name Duricef is discontinued, and cefadroxil is available in generic form. Common side effects of Duricef (cefadroxil) include:
- stomach upset or pain,
- stiff or tight muscles,
- joint pain,
- feeling restless or hyperactive,
- unusual or unpleasant taste in your mouth,
- itching or skin rash, or
- vaginal itching or discharge.
Tell your doctor if you have unlikely but very serious side effects of Duricef (cefadroxil) including:
- persistent nausea or vomiting,
- yellowing eyes or skin,
- dark urine,
- new signs of infection (e.g., persistent sore throat or fever),
- easy bruising or bleeding,
- changes in the amount of urine, or
- mental/mood changes (such as confusion).
The recommended adult dose of cefadroxil for treating pharyngitis, skin and skin structure infections, and tonsillitis is 1 gram daily as a single dose or in two divided doses. The dose for urinary tract infections is 2 grams once daily or in two divided doses. The dose for preventing endocarditis is 2 grams given one hour before a procedure. The recommended dose for children is 30 mg/kg/day as a single dose or two divided doses. There may be other drugs that can interact with cefadroxil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start taking a new medication without telling your doctor. This medication should be used only when prescribed during pregnancy. This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.
Our Duricef (cefadroxil) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
- diarrhea that is watery or bloody;
- fever, chills, body aches, flu symptoms;
- unusual bleeding or bruising;
- seizure (convulsions);
- pale or yellowed skin, dark colored urine, fever, confusion or weakness;
- jaundice (yellowing of the skin or eyes);
- fever, swollen glands, rash or itching, joint pain, or general ill feeling;
- fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
- increased thirst, loss of appetite, swelling, weight gain, feeling short of breath, urinating less than usual or not at all.
Less serious side effects may include:
- nausea, vomiting, stomach pain, mild diarrhea;
- stiff or tight muscles;
- joint pain;
- feeling restless or hyperactive;
- unusual or unpleasant taste in your mouth;
- mild itching or skin rash; or
- vaginal itching or discharge.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Read the entire detailed patient monograph for Duricef (Cefadroxil)
Other reactions have included hepatic dysfunction including cholestasis and elevations in serum transaminase, genital pruritus, genital moniliasis, vaginitis, moderate transient neutropenia, fever. Agranulocytosis, thrombocytopenia, idiosyncratic hepatic failure, erythema multiforme, Stevens-Johnson syndrome, serum sickness, and arthralgia have been rarely reported.
In addition to the adverse reactions listed above which have been observed in patients treated with cefadroxil, the following adverse reactions and altered laboratory tests have been reported for cephalosporin-class antibiotics:
Toxic epidermal necrolysis, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, increased BUN, increased creatinine, elevated alkaline phosphatase, elevated aspartate aminotransferase (AST), elevated alanine aminotransferase (ALT), elevated bilirubin, elevated LDH, eosinophilia, pancytopenia, neutropenia.
Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced (see DOSAGE AND ADMINISTRATION and OVERDOSAGE). If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated.
Read the entire FDA prescribing information for Duricef (Cefadroxil)