Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 11/9/2021
Durlaza Side Effects Center

What Is Durlaza?

Durlaza (aspirin) Extended Release is a nonsteroidal anti-inflammatory drug (NSAID) indicated to reduce the risk of death and myocardial infarction (MI) in patients with chronic coronary artery disease, such as patients with a history of MI or unstable angina pectoris or with chronic stable angina and to reduce the risk of death and recurrent stroke in patients who have had an ischemic stroke or transient ischemic attack.

What Are Side Effects of Durlaza?

Common side effects of Durlaza include:

Dosage for Durlaza

The recommended dose of Durlaza is 162.5 mg per day with a full glass of water at the same time each day.

What Drugs, Substances, or Supplements Interact with Durlaza?

Durlaza may interact with alcohol, renin-angiotensin system (RAS) inhibitors, anticoagulants, antiplatelet drugs, anticonvulsants, methotrexate, and other NSAIDs. Tell your doctor all medications and supplements you use.

Durlaza During Pregnancy or Breastfeeding

During pregnancy, Durlaza should only be used if prescribed; it may harm a fetus. Avoid use of Durlaza during the third trimester of pregnancy. Because of the potential for adverse reactions in nursing infants, Durlaza is not recommended for use while breastfeeding.

Additional Information

Our Durlaza (aspirin) Extended Release Capsules Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Heart Disease: Symptoms, Signs, and Causes See Slideshow
Durlaza Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using aspirin and call your doctor at once if you have:

  • ringing in your ears, confusion, hallucinations, rapid breathing, seizure (convulsions);
  • severe nausea, vomiting, or stomach pain;
  • bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • fever lasting longer than 3 days; or
  • swelling, or pain lasting longer than 10 days.

Common side effects may include:

  • upset stomach, heartburn;
  • drowsiness; or
  • mild headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Durlaza (Aspirin Capsules)


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Durlaza Professional Information


Clinical Trials Experience

The following is a list of adverse reactions that have been reported in the literature for products containing low dose aspirin [see WARNINGS AND PRECAUTIONS].

Central Nervous System: Agitation, cerebral edema, coma, confusion, dizziness, headache, lethargy, seizures.

Fluid and Electrolyte: Hyperkalemia, metabolic acidosis, respiratory alkalosis.

Gastrointestinal: Dyspepsia, hepatic enzyme elevation, hepatitis, Reye's Syndrome

Renal: Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure.

Read the entire FDA prescribing information for Durlaza (Aspirin Capsules)


In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

© Durlaza Patient Information is supplied by Cerner Multum, Inc. and Durlaza Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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