Dxevo Side Effects Center

Last updated on RxList: 12/11/2019
Dxevo Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 12/11/2019

What Is Dxevo?

Dxevo (dexamethasone 1.5 mg tablet) is an adrenocortical steroid used to treat allergies, skin diseases, endocrine disorders, gastrointestinal diseases, blood disorders, cancers, eye diseases, kidney diseases, lung diseases, rheumatic disorders, and nervous system conditions. Dxevo is also used for diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy.

What Are Side Effects of Dxevo?

Common side effects of Dxevo include:

Dosage for Dxevo

The initial dosage of Dxevo varies from 0.75 to 9 mg a day depending on the disease being treated.

Dxevo In Children

The efficacy and safety of corticosteroids such as Dxevo in the pediatric population are based on the well-established course of effect of corticosteroids, which is similar in pediatric and adult populations. Published studies provide evidence of efficacy and safety in pediatric patients for the treatment of nephrotic syndrome (patients under 2 years of age), and aggressive lymphomas and leukemias (patients under 1 month of age). Other indications for pediatric use of corticosteroids, e.g., severe asthma and wheezing, are based on adequate and well-controlled trials conducted in adults, on the premises that the course of the diseases and their pathophysiology are considered to be substantially similar in both populations.

What Drugs, Substances, or Supplements Interact with Dxevo?

Dxevo may interact with other medicines such as:

  • aminoglutethimide,
  • amphotericin B injection and potassium-depleting agents,
  • macrolide antibiotics,
  • anticholinesterases,
  • oral anticoagulants,
  • antidiabetics,
  • antitubercular drugs,
  • cholestyramine,
  • cyclosporine,
  • digitalis glycosides,
  • ephedrine,
  • estrogens (including oral contraceptives),
  • hepatic enzyme inducers, inhibitors and substrates (e.g., barbiturates, phenytoin, carbamazepine, rifampin, ketoconazole, indinavir, erythromycin),
  • ketoconazole,
  • nonsteroidal anti-inflammatory drugs (NSAIDs),
  • phenytoin,
  • thalidomide,
  • skin tests,
  • dexamethasone suppression tests (DST), and
  • vaccines

Tell your doctor all medications and supplements you use and all vaccines you recently received.

Dxevo During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Dxevo; it may harm a fetus. Systemically administered corticosteroids such as Dxevo pass into breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding while using Dxevo is not recommended.

Additional Information

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Allergies can best be described as: See Answer
Dxevo Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • muscle tightness, weakness, or limp feeling;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • severe depression, unusual thoughts or behavior;
  • a seizure (convulsions);
  • bloody or tarry stools, coughing up blood;
  • fast or slow heart rate, weak pulse;
  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting;
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling; or
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed.

Dexamethasone can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Common side effects may include:

  • fluid retention (swelling in your hands or ankles);
  • increased appetite;
  • mood changes, trouble sleeping;
  • skin rash, bruising or discoloration;
  • acne, increased sweating, increased hair growth;
  • headache, dizziness;
  • nausea, vomiting, upset stomach;
  • changes in your menstrual periods; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Dxevo Professional Information

SIDE EFFECTS

(lis ted alphabetically, under each s ubs ection)

The following adverse reactions have been reported with dexamethasone or other corticosteroids:

Allergic Reactions: Anaphylactoid reaction, anaphylaxis, angioedema.

Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS: Cardio-Renal), edema, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis.

Dermatologic: Acne, allergic dermatitis, dry scaly skin, ecchymoses and petechiae, erythema, impaired wound healing, increased sweating, rash, striae, suppression of reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria.

Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, hyperglycemia, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients.

Fluid and Electrolyte Disturbances: Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention, tumor lysis syndrome.

Gastrointestinal: Abdominal distention, elevation in serum liver enzyme levels (usually reversible upon discontinuation), hepatomegaly, increased appetite, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis.

Metabolic: Negative nitrogen balance due to protein catabolism.

Musculoskeletal: Aseptic necrosis of femoral and humeral heads, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures.

Neurological/Psychiatric: Convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, insomnia, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychic disorders, vertigo.

Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts.

Other: Abnormal fat deposits, decreased resistance to infection, hiccups, increased or decreased motility and number of spermatozoa, malaise, moon face, weight gain.

Read the entire FDA prescribing information for Dxevo (Dexamethasone Tablets )

© Dxevo Patient Information is supplied by Cerner Multum, Inc. and Dxevo Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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