Last updated on RxList: 9/8/2020
Dyrenium Side Effects Center

What Is Dyrenium?

Dyrenium (triamterene) is a potassium-sparing diuretic (water pill) used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney condition called nephrotic syndrome. Dyrenium is also used to treat edema caused by having too much aldosterone in your body. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in your body.

What Are Side Effects of Dyrenium?

Common side effects of Dyrenium include dizziness, tiredness, headache, stomach upset, nausea, vomiting, or diarrhea as your body adjusts to the medication. Other side effects of Dyrenium include increased sensitivity to the sun, dry mouth, or skin rash.

Dosage for Dyrenium

The usual starting dose of Dyrenium when used alone is 100 mg twice daily after meals.

What Drugs, Substances, or Supplements Interact with Dyrenium?

Dyrenium may interact with lithium, insulin or oral diabetes medicine, ACE inhibitors, indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs). Tell your doctor all medications you use.

Dyrenium During Pregnancy and Breastfeeding

Dyrenium should be used only when prescribed during pregnancy. This drug may pass into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Dyrenium (triamterene) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Dyrenium Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using triamterene and call your doctor at once if you have:

  • pale skin, easy bruising or bleeding;
  • slow, fast, or uneven heartbeat;
  • jaundice (yellowing of the skin or eyes);
  • little or no urinating;
  • signs of a kidney stone--sudden pain in your back or side, vomiting, fever, chills, painful urination, and urine that looks, red, pink, brown, or cloudy; or
  • high potassium level--nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement.

Common side effects may include:

  • nausea, diarrhea;
  • dizziness, headache;
  • dry mouth; or
  • feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dyrenium (Triamterene)


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Dyrenium Professional Information


Adverse effects are listed in decreasing order of frequency; however, the most serious adverse effects are listed first, regardless of frequency. All adverse effects occur rarely (that is, 1 in 1000, or less).

Hypersensitivity: anaphylaxis, rash, photosensitivity.

Metabolic: hyperkalemia, hypokalemia.

Renal: azotemia, elevated BUN and creatinine, renal stones, acute interstitial nephritis (rare), acute renal failure (one case of irreversible renal failure has been reported).

Gastrointestinal: jaundice and/or liver enzyme abnormalities, nausea and vomiting, diarrhea.

Hematologic: thrombocytopenia, megaloblastic anemia.

Central Nervous System: weakness, fatigue, dizziness, headache, dry mouth.

To report SUSPECTED ADVERSE REACTIONS, contact Concordia Pharmaceuticals at 1-877-370-1142 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Read the entire FDA prescribing information for Dyrenium (Triamterene)

© Dyrenium Patient Information is supplied by Cerner Multum, Inc. and Dyrenium Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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