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Last reviewed on RxList: 7/18/2016
Edecrin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 01/26/2017

Edecrin (ethacrynic acid) is a loop diuretic (water pill) used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Common side effects of Edecrin include:

Using too much Edecrin can lead to serious water and mineral loss (dehydration). Tell your doctor if you have unlikely but serious symptoms of dehydration including loss of appetite, confusion, severe dizziness, fainting, unusual dry mouth, thirst, severe headache, fast or irregular heartbeat, muscle cramps or spasms, nausea, vomiting, numbness and tingling, seizure, decrease in amount of urine, or unusual weakness or tiredness.

The smallest dose of Edecrin should be given to produce gradual weight loss (about 1 to 2 pounds per day). Onset of diuresis usually occurs at 50 to 100 mg for adults. After diuresis has been achieved, the minimally effective dose (usually from 50 to 200 mg daily) may be given on a continuous or intermittent dosage schedule. Edecrin may interact with lithium, digoxin, blood thinners, other diuretics, steroids, cancer medicines, cephalosporin antibiotics, aspirin and other salicylates, NSAIDs (nonsteroidal anti-inflammatory drugs), amikacin, gentamicin, netilmicin, streptomycin, or tobramycin. During pregnancy, Edecrin should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Edecrin (ethacrynic acid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Edecrin Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using ethacrynic acid and call your doctor at once if you have any of these serious side effects:

  • dry mouth, thirst, nausea, vomiting;
  • feeling weak, drowsy, restless, or light-headed;
  • fast or uneven heartbeat;
  • muscle pain or weakness;
  • easy bruising or bleeding, unusual weakness;
  • fever, chills, body aches, flu symptoms;
  • severe or watery diarrhea;
  • blood in your urine or stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • rapid weight loss;
  • hearing loss, feeling of fullness in the ear; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • mild diarrhea, stomach pain, loss of appetite;
  • trouble swallowing;
  • headache; or
  • dizziness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Edecrin (Ethacrynic Acid)

Edecrin Professional Information



Anorexia, malaise, abdominal discomfort or pain, dysphagia, nausea, vomiting, and diarrhea have occurred. These are more frequent with large doses or after one to three months of continuous therapy. A few patients have had sudden onset of profuse, watery diarrhea. Discontinue EDECRIN if diarrhea is severe and do not give it again. Gastrointestinal bleeding has occurred in some patients. Rarely, acute pancreatitis has been reported.


Reversible hyperuricemia and acute gout have been reported. Acute symptomatic hypoglycemia with convulsions occurred in two uremic patients who received doses above those recommended. Hyperglycemia has been reported. Rarely, jaundice and abnormal liver function tests have been reported in seriously ill patients receiving multiple drug therapy, including EDECRIN.


Agranulocytosis or severe neutropenia has been reported in a few critically ill patients also receiving agents known to produce this effect. Thrombocytopenia has been reported rarely. Henoch-Sch´┐Żnlein purpura has been reported rarely in patients with rheumatic heart disease receiving multiple drug therapy, including EDECRIN.

Special Senses


Deafness, tinnitus and vertigo with a sense of fullness in the ears, and blurred vision have occurred.

Central Nervous System

Headache, fatigue, apprehension, confusion.


Skin rash, fever, chills, hematuria.

SODIUM EDECRIN occasionally has caused local irritation and pain after intravenous use.

Read the entire FDA prescribing information for Edecrin (Ethacrynic Acid)

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© Edecrin Patient Information is supplied by Cerner Multum, Inc. and Edecrin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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