Edema: The swelling of soft tissues as a result of excess fluid accumulation. Edema is often most prominent in the lower legs and feet toward the end of the day because fluid pools while people maintain an upright position. SLIDESHOW Spider & Varicose Veins: Causes, Before and After Treatment Images See Slideshow From Featured Centers What Are the Best PsA Treatments for You?Understanding Biologics 10 Things People With Depression Wish You Knew Health Solutions From Our Sponsors Shot-Free MS Treatment Your Child and COVID-19