Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 2/15/2022
EEMT Side Effects Center

What Is EEMT?

EEMT (esterified estrogens and methyltestosterone) is a combination of the female hormone estrogen and the male hormone testosterone used to treat moderate to severe vasomotor symptoms associated with menopause in those patients not improved by estrogens alone.

What Are Side Effects of EEMT?

Common side effects of EEMT include:

Dosage for EEMT

The usual dosage range is 1 tablet of EEMT full strength or 1 to 2 tablets of EEMT half strength daily as recommended by the physician.

What Drugs, Substances, or Supplements Interact with EEMT?

EEMT may interact with anticoagulants, oxyphenbutazone, and insulin. Tell your doctor all medications and supplements you use.

EEMT During Pregnancy or Breastfeeding

EEMT is not recommended for use during pregnancy. It may harm a fetus. It is unknown if this drug passes into breast milk. Because many drugs pass into breast milk, consult your doctor before breastfeeding.

Additional Information

Our EEMT (esterified estrogens and methyltestosterone) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer
EEMT Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • swelling or tenderness in your stomach;
  • nausea, vomiting, swelling, rapid weight gain;
  • jaundice (yellowing of the skin or eyes);
  • changes in skin color;
  • a light-headed feeling, like you might pass out;
  • unusual vaginal bleeding;
  • a breast lump;
  • memory problems, confusion, unusual behavior;
  • high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy; or

Methyltestosterone can cause symptoms of male features in a woman taking this medicine. Call your doctor if you develop enlarged genitals, male-pattern baldness, excessive body hair growth, increased acne, irregular menstrual periods, or any signs of male characteristics.

Common side effects may include:

  • swollen or painful breasts;
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding;
  • pain or burning when you urinate;
  • nausea, vomiting, stomach cramps;
  • darkening of facial skin, increased hair growth, loss of scalp hair;
  • vision changes, problems with contact lenses;
  • swelling, weight gain or loss;
  • increased or decreased libido;
  • headache, dizziness, depression, anxiety; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for EEMT (Esterified Estrogens and Methyltestosterone Tablets)


What Is Osteoporosis? Treatment, Symptoms, Medication See Slideshow
EEMT Professional Information


Associated with Estrogens

(See WARNINGS regarding induction of neoplasia, adverse effects on the fetus, increased incidence of gallbladder disease, and adverse effects similar to those of oral contraceptives, including thromboembolism). The following additional adverse reactions have been reported with estrogenic therapy, including oral contraceptives:

Genitourinary system

Breakthrough bleeding, spotting, change in menstrual flow.
Premenstrual-like syndrome.
Amenorrhea during and after treatment.
Increase in size of uterine fibromyomata.
Vaginal candidiasis.
Change in cervical erosion and in degree of cervical secretion.
Cystitis-like syndrome.


Tenderness, enlargement, secretion.


Nausea, vomiting.
Abdominal cramps, bloating.
Cholestatic jaundice.


Chloasma or melasma which may persist when drug is discontinued.
Erythema multiforme.
Erythema nodosum.
Hemorrhagic eruption.
Loss of scalp hair.


Steepening of corneal curvature.
Intolerance to contact lenses.


Headache, migraine, dizziness.
Mental depression.


Increase or decrease in weight.
Reduced carbohydrate tolerance.
Aggravation of porphyria.
Changes in libido.

Associated with Methyltestosterone

Endocrine And Urogenital
  1. Female: The most common side effects of androgen therapy are amenorrhea and other menstrual irregularities, inhibition of gonadotropin secretion, and virilization, including deepening of the voice and clitoral enlargement. The latter usually is not reversible after androgens are discontinued. When administered to a pregnant woman androgens cause virilization of external genitalia of the female fetus.
  2. Skin and Appendages: Hirsutism, male pattern of baldness, and acne.
  3. Fluid and Electrolyte Disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates.
  4. Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function test, rarely hepatocellular neoplasms, and peliosis hepatis (see WARNINGS).
  5. Hematologic: Suppression of clotting factors, II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia.
  6. Nervous System: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia.
  7. Metabolic: Increased serum cholesterol.
  8. Miscellaneous: Inflammation and pain at site of intramuscular injection or subcutaneous implantation of testosterone containing pellets, stomatitis with buccal preparations, and rarely anaphylactoid reactions.

Read the entire FDA prescribing information for EEMT (Esterified Estrogens and Methyltestosterone Tablets)

© EEMT Patient Information is supplied by Cerner Multum, Inc. and EEMT Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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