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Effient vs. Xarelto

Reviewed on 5/9/2019

Are Effient and Xarelto the Same Thing?

Effient (prasugrel) and Xarelto (rivaroxaban) are used to prevent blood clots.

Effient is used in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.

Xarelto is indicated for the prevention of deep vein thrombosis, which may lead to pulmonary embolism in patients undergoing knee or hip replacement surgery.

Effient and Xarelto belong to different drug classes. Effient is an antiplatelet drug and Xarelto is a Factor Xa inhibitor.

Side effects of Effient and Xarelto that are similar include increased tendency for bleeding and pain in your arms or legs.

Side effects of Effient that are different from Xarelto include headache, dizziness, back pain, minor chest pain, tired feeling, fatigue, nausea, cough, high or low blood pressure (hypertension or hypotension), shortness of breath, slow heart rate, rash, fever, swelling in the extremities, and diarrhea.

Side effects of Xarelto that are different from Effient include fainting, itching, muscle pain, and muscle spasms.

Both Effient and Xarelto may interact with other medicines used to prevent blood clots or nonsteroidal anti-inflammatory drugs (NSAIDs).

Xarelto may also interact with antibiotics, antifungals, aspirin and other salicylates, bosentan, conivaptan, dexamethasone, rifamycins, St. John's wort, quinidine, verapamil, barbiturates, heart or blood pressure medications, HIV medications, medicines to treat narcolepsy, seizure medications, dextran, and cilostazol.

QUESTION

What is a stroke? See Answer

What Are Possible Side Effects of Effient?

Common side effects of Effient include:

  • an increased tendency for bleeding,
  • headache,
  • dizziness,
  • back pain,
  • minor chest pain,
  • tired feeling,
  • fatigue,
  • nausea,
  • cough,
  • high or low blood pressure (hypertension or hypotension),
  • shortness of breath,
  • slow heart rate,
  • rash,
  • fever,
  • swelling or pain in the extremities, and
  • diarrhea.

What Are Possible Side Effects of Xarelto?

Common side effects of Xarelto include:

  • bleeding complications, including major bleeding events.

Other side effects of Xarelto include:

  • fainting,
  • itching,
  • pain in your arms or legs,
  • muscle pain, and
  • muscle spasms.

Xarelto side effects that are severe are spinal hematomas that may develop after spinal surgery with this drug.

What Is Effient?

Effient (prasugrel) is an antiplatelet drug that prevents the platelets in the bloodstream from aggregating and forming blood clots, used to prevent blood clots in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.

What Is Xarelto?

Xarelto (rivaroxaban) is a Factor Xa inhibitor indicated for the prevention of deep vein thrombosis which may lead to pulmonary embolism in patients undergoing knee or hip replacement surgery.

What Drugs Interact With Effient?

Effient may interact with NSAIDs (nonsteroidal anti-inflammatory drugs) or warfarin. Tell your doctor all medications and supplements you use. There are no adequate and well-controlled studies of Effient use in pregnant women, although studies in animals did not show any evidence of harm to the developing fetus. Effient should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus. It is unknown whether prasugrel is excreted in human milk.

What Drugs Interact With Xarelto?

Xarelto may also interact with dexamethasone, barbiturates, seizure medications, and medicines to treat narcolepsy.

SLIDESHOW

Stroke Causes, Symptoms, and Recovery See Slideshow

How Should Effient Be Taken?

Effient treatment is started as a single 60-mg oral loading dose and then continued at 10 mg orally once daily. Patients taking Effient should also take aspirin (75 mg to 325 mg) daily.

How Should Xarelto Be Taken?

Take Xarelto exactly as your healthcare provider tells you to take it.

Your healthcare provider will tell you how much Xarelto to take and when to take it.

Your healthcare provider may change your dose if needed.

Take Xarelto about 1 hour before sexual activity. You may take Xarelto between 30 minutes to 4 hours before sexual activity if needed.

Xarelto can be taken with or without food. If you take Xarelto after a high fat meal (such as a cheeseburger and french fries), Xarelto may take a little longer to start working

Do not take Xarelto more than 1 time a day.

If you accidentally take too much Xarelto, call your doctor or go to the nearest hospital emergency room right away.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

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If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References

Lilly Effient Drug Information.

https://pi.lilly.com/us/effient.pdf

Xarelto Prescribing Information.

https://www.xareltohcp.com/shared/product/xarelto/medication-guide.pdf
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