Emgality vs. Trokendi XR

Reviewed on 9/17/2019

Are Emgality and Trokendi XR the Same Thing?

Emgality (galcanezumab-gnlm) and Trokendi XR (topiramate) are used to prevent migraine in adults.

Trokendi XR is also used as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures and adjunctive therapy in patients 6 years of age and older with partial onset or primary generalized tonic-clonic seizures.

Emgality is a calcitonin-gene related peptide antagonist and Trokendi XR is a sulfamate-substituted monosaccharide.

Side effects of Emgality that are different from Trokendi XR include injection site reactions (such as pain, redness, and itching).

Side effects of Trokendi XR that are different from Emgality include tingling sensations in the arms and legs, dizziness, diarrhea, nausea, loss of appetite, changes in taste, weight loss, sleepiness, nervousness, memory problems, insomnia, depression, difficulty concentrating, anxiety, infections, drowsiness, weakness, numbness, psychomotor slowing, loss of coordination, bronchitis, confusion, mood changes, runny nose, leg pain, acne, constipation, rash, itching, dry mouth, urinary problems, chest pain, gastroesophageal reflux (GERD), anemia, and shortness of breath.

Emgality may interact with other drugs.

Trokendi XR may interact with alcohol, oral contraceptives, antiepileptic drugs, CNS depressants, carbonic anhydrase inhibitors, metformin, and lithium.

What Are Possible Side Effects of Emgality?

Common side effects of Emgality include:

  • injection site reactions such as pain, redness, and itching

What Are Possible Side Effects of Trokendi XR?

Common side effects of Trokendi XR include:

  • tingling sensations in the arms and legs,
  • dizziness,
  • diarrhea,
  • nausea,
  • loss of appetite,
  • changes in taste,
  • weight loss,
  • sleepiness,
  • nervousness,
  • memory problems,
  • insomnia,
  • depression,
  • difficulty concentrating,
  • anxiety,
  • infections,
  • drowsiness,
  • weakness,
  • numbness,
  • psychomotor slowing,
  • loss of coordination,
  • bronchitis,
  • confusion,
  • mood changes,
  • runny nose,
  • leg pain,
  • acne,
  • constipation,
  • rash,
  • itching,
  • dry mouth,
  • urinary problems,
  • chest pain,
  • gastroesophageal reflux (GERD),
  • anemia, and
  • shortness of breath.

A small percent of patients taking Trokendi XR may experience suicidal ideation. If you have thoughts of suicide, tell your doctor immediately.

What Is Emgality?

Emgality (galcanezumab-gnlm) is a calcitonin-gene related peptide antagonist indicated for the preventive treatment of migraine in adults.

What Is Trokendi XR?

Trokendi XR (topiramate) Extended-release is a sulfamate-substituted monosaccharide used as initial monotherapy in patients 10 years of age and older with partial onset or primary generalized tonic-clonic seizures and adjunctive therapy in patients 6 years of age and older with partial onset or primary generalized tonic-clonic seizures.

QUESTION

Who suffers more frequently from migraine headaches? See Answer

What Drugs Interact With Emgality?

Emgality may interact with other drugs. Tell your doctor all medications and supplements you use.

What Drugs Interact With Trokendi XR?

Trokendi XR may interact with other seizure medications, other medicines that can make you sleepy (cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for depression or anxiety), metformin, and lithium.

Trokendi XR may also interact with alcohol, oral contraceptives, and carbonic anhydrase inhibitors.

How Should Emgality Be Taken?

The recommended dosage of Emgality is a 240 mg loading dose (administered as two consecutive injections of 120 mg each), followed by monthly doses of 120 mg.

How Should Trokendi XR Be Taken?

The recommended dose for Trokendi XR monotherapy in adults and pediatric patients 10 years of age and older is 400 mg orally once daily.

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References
Lilly. Emgality Drug Information.

www.emgality.com/?

Supernus Pharmaceuticals, Inc. Trokendi XR Product Information.

https://www.trokendixr.com

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