Enbrel vs. Cosentyx

Are Enbrel and Cosentyx the Same Thing?

Enbrel (etanercept) and Cosentyx (secukinumab) are used to treat plaque psoriasis.

Enbrel is also used to treat certain autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis.

Enbrel and Cosentyx belong to different drug classes. Enbrel is a tumor necrosis factor (TNF) inhibitor and Cosentyx is a human interleukin-17A antagonist.

Side effects of Enbrel and Cosentyx that are similar include diarrhea.

Side effects of Enbrel that are different from Cosentyx include mild nausea, vomiting, stomach pain, headache, redness or discomfort at the injection site, heartburn, weight changes, cold symptoms (cough, runny nose), or weakness.

Side effects of Cosentyx that are different from Enbrel include sore throat and nose, upper respiratory tract infection, sinus infection (sinusisits), stuffy or runny nose, oral herpes, hives, athlete's foot, tonsillitis, oral thrush, impetigo, inflammatory bowel disease, ear infection, eye infection or inflammation (conjunctivitis), increased liver transaminases, and low white blood cell count (neutropenia).

Enbrel may interact with anakinra, cyclophosphamide, sulfasalazine, or drugs that weaken your immune system (such as cancer medicine or steroids).

Cosentyx may interact with warfarin, cyclosporine, or "live" vaccines.

What Are Possible Side Effects of Enbrel?

Common side effects of Enbrel include:

  • Mild nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Headache
  • Redness or discomfort at the injection site
  • Heartburn
  • Weight changes
  • Cold symptoms (cough, runny nose)
  • Weakness

Serious side effects include:

  • Seizures
  • Bruising
  • Bleeding
  • Skin changes (rash, pustules, blisters, patchy skin color, red spots, or a butterfly-shaped rash over cheeks and nose)
  • Swelling
  • Difficulty breathing or swallowing
  • Numbness and tingling, burning pain
  • Vision changes
  • Dizziness
  • Signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms, itching, swelling, warmth, redness, or oozing),
  • Rapid weight gain
  • Chest pain
  • Ongoing cough
  • Coughing up mucus or blood
  • Black, bloody, or tarry stools
  • Changes in mood or personality (in children)
  • Joint pain or swelling with fever, swollen glands, muscle aches, chest pain, unusual thoughts or behavior, and/or seizures (convulsions)

What Are Possible Side Effects of Cosentyx?

Common side effects of Cosentyx include:

  • sore throat and nose,
  • diarrhea,
  • upper respiratory tract infection,
  • sinus infection (sinusisits),
  • stuffy or runny nose,
  • oral herpes,
  • hives,
  • athlete's foot,
  • tonsillitis,
  • oral thrush,
  • impetigo,
  • inflammatory bowel disease,
  • ear infection,
  • eye infection or inflammation (conjunctivitis),
  • increased liver transaminases, and
  • low white blood cell count (neutropenia).

What Is Enbrel?

Enbrel (etanercept) is a tumor necrosis factor inhibitor used to treat certain autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and plaque psoriasis.

What Is Cosentyx?

Cosentyx (secukinumab) for Injection is a human interleukin-17A antagonist used to treat moderate to severe plaque psoriasis in adult patients who are candidates for systemic therapy or phototherapy.

QUESTION

Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer

What Drugs Interact With Enbrel?

Enbrel may interact with anakinra, cyclophosphamide, sulfasalazine, or drugs that weaken your immune system (such as cancer medicine or steroids). Tell your doctor all medications and supplements you use.

What Drugs Interact With Cosentyx?

Cosentyx may interact with warfarin, cyclosporine, or "live" vaccines. Tell your doctor all medications and supplements you use and all vaccines you recently received. Tell your doctor if you are pregnant or plan to become pregnant before using Cosentyx. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

How Should Enbrel Be Taken?

Enbrel is available in three preparations; 0.98 mL of a 50 mg/mL solution of etanercept, 0.51 mL of a 50 mg/mL solution of etanercept and 25 mg etanercept. All are used for injection; only the 25 mg strength is available in a multiuse vial, the others are available in a prefilled syringe. Starting dose is often 50 mg injected twice a week in adults and 0.8 mg per Kg in pediatric patients weighing less than 63 Kg. Other doses may be used.

How Should Cosentyx Be Taken?

The recommended dose of Cosentyx is 300 mg by subcutaneous injection at Weeks 0, 1, 2, 3, and 4 followed by 300 mg every 4 weeks. Each 300 mg dose is given as 2 subcutaneous injections of 150 mg.

SLIDESHOW

Types of Psoriasis: Medical Pictures and Treatments See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
Amgen. Enbrel Product Information.
https://www.enbrel.com
Novartis. Cosentyx Product Monograph.
http://www.cosentyx.com

Health Solutions From Our Sponsors