Enbrel vs. Hadlima

Are Enbrel and Hadlima the Same Thing?

Enbrel (etanercept) and Hadlima (adalimumab-bwwd) are tumor necrosis factor (TNF) blockers used to treat rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and plaque psoriasis (Ps).

Hadlima is also used to treat adult Crohn's disease (CD) and ulcerative colitis (UC).

Hadlima is biosimilar to Humira (adalimumab).

Side effects of Enbrel that are different from Hadlima include mild nausea, vomiting, diarrhea, stomach pain, heartburn, weight changes, cold symptoms (cough, runny nose), and weakness.

Side effects of Enbrel and Hadlima that are similar include headache and injection site reactions (discomfort, redness, itching, bleeding, pain, and swelling).

Side effects of Hadlima that are different from Enbrel include infections (e.g. upper respiratory tract, sinusitis) and rash.

Both Hadlima and Enbrel may interact with abatacept, anakinra, and live vaccines.

Enbrel may also interact with cyclophosphamide, sulfasalazine, insulin or oral diabetes medicines, and drugs that weaken your immune system (such as cancer medicines or steroids).

Hadlima may also interact with warfarin, cyclosporine, and theophylline.

What Are Possible Side Effects of Enbrel?

Side effects of Enbrel include:

  • Mild nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Headache
  • Redness or discomfort at the injection site
  • Heartburn
  • Weight changes
  • Cold symptoms (cough, runny nose)
  • Weakness

Serious side effects include:

  • Seizures
  • Bruising
  • Bleeding
  • Skin changes (rash, pustules, blisters, patchy skin color, red spots, or a butterfly-shaped rash over cheeks and nose)
  • Swelling
  • Difficulty breathing or swallowing
  • Numbness and tingling, burning pain
  • Vision changes
  • Dizziness
  • Signs of infection (fever, chills, sore throat, body aches, confusion, neck stiffness, flu symptoms, itching, swelling, warmth, redness, or oozing),
  • Rapid weight gain
  • Chest pain
  • Ongoing cough
  • Coughing up mucus or blood
  • Black, bloody, or tarry stools
  • Changes in mood or personality (in children)
  • Joint pain or swelling with fever, swollen glands, muscle aches, chest pain, unusual thoughts or behavior, and/or seizures (convulsions)

What Are Possible Side Effects of Hadlima?

Common side effects of Hadlima include:

  • infections (e.g. upper respiratory tract, sinusitis),
  • injection site reactions (redness, itching, bleeding, pain, and swelling),
  • headache, and
  • rash


The term arthritis refers to stiffness in the joints. See Answer

What Is Enbrel?

Enbrel (etanercept) is a tumor necrosis factor inhibitor used to treat certain autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, and plaque psoriasis.

What Is Hadlima?

Hadlima (adalimumab-bwwd) is a tumor necrosis factor (TNF) blocker indicated for treatment of rheumatoid Arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), adult Crohn's disease (CD), ulcerative colitis (UC), and plaque psoriasis (Ps). Hadlima is biosimilar to Humira (adalimumab).

What Drugs Interact With Enbrel?

Enbrel may interact with anakinra, cyclophosphamide, sulfasalazine, or drugs that weaken your immune system (such as cancer medicine or steroids). Tell your doctor all medications and supplements you use.

What Drugs Interact With Hadlima?

Hadlima may interact with abatacept, anakinra, warfarin, cyclosporine, theophylline, and live vaccines.


What Is Rheumatoid Arthritis (RA)? Symptoms, Treatment, Diagnosis See Slideshow

How Should Enbrel Be Taken?

Enbrel is given by injection under the skin, in the stomach or thigh area, as directed by your doctor. Follow your doctor's directions and the schedule for your doses very carefully.

How Should Hadlima Be Taken?

Enbrel is available in three preparations; 0.98 mL of a 50 mg/mL solution of etanercept, 0.51 mL of a 50 mg/mL solution of etanercept and 25 mg etanercept. All are used for injection; only the 25 mg strength is available in a multiuse vial, the others are available in a prefilled syringe. Starting dose is often 50 mg injected twice a week in adults and 0.8 mg per Kg in pediatric patients weighing less than 63 Kg. Other doses may be used.


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Amgen. Enbrel Product Information.


FDA. Hadlima Product Information.


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