Aspirin oxycodone

Reviewed on 9/12/2022

What Is Aspirin and oxycodone and How Does It Work?

Aspirin and oxycodone is a combination prescription medication used for relieving moderate to severe pain. 

  • Aspirin and oxycodone are available under various brand names: Endodan, Percodan

What Are Side Effects Associated with Using Aspirin and oxycodone?

Common side effects of Aspirin and oxycodone include:

  • stomach pain, nausea, vomiting, constipation;
  • headache, dizziness, drowsiness, tiredness;
  • rash; or
  • fever.

Serious side effects of Aspirin and oxycodone include:

  • hives,
  • difficult breathing,
  • swelling of the face, lips, tongue, or throat.
  • weak or shallow breathing, breathing that stops during sleep;
  • severe constipation;
  • confusion, unusual thoughts or behavior, feeling like you might pass out;
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; or
  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, feeling weak or tired.
  • serotonin syndrome, such as agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Rare side effects of Aspirin and oxycodone include:

  • none

Seek medical care or call 911 at once if you have the following serious side effects:

  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.
  • Severe eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
  • Severe heart symptoms include fast, irregular, or pounding heartbeats; fluttering in the chest; shortness of breath; sudden dizziness, lightheadedness, or passing out.

This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.


Back Pain: 16 Back Pain Truths and Myths See Slideshow

What Are Dosages of Aspirin and oxycodone?

Adult and pediatric dosage

Tablet: Schedule II

  • 4.8355 mg/325 mg

Relief of Moderate to Moderately Severe Pain

Adult dosage

  • Usual: 1 tablet orally every 6 hours or as needed
  • Maximum: 12 tablets (4 grams aspirin) per 24 hours

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Other Drugs Interact with Aspirin and oxycodone?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first

  • Aspirin and oxycodone have severe interactions with the following drugs:
  • Aspirin and oxycodone have serious interactions with at least 93 other drugs.
  • Aspirin and oxycodone have moderate interactions with at least 499 other drugs.
  • Aspirin and oxycodone have minor interactions with at least 132 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions or concerns.

What Are Warnings and Precautions for Aspirin and oxycodone?


  • Allergic to aspirin or oxycodone
  • Severe asthma or breathing problems;
  • Hemophilia (a bleeding disorder); or
  • A stomach or bowel obstruction (including paralytic ileus)
  • Children.

Effects of drug abuse

  • Addiction,
  • Overdose, or
  • Death.

Short-Term Effects

  • See “What Are Side Effects Associated with Using Aspirin and oxycodone?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Aspirin and oxycodone?”


  • Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.
  • Fatal side effects may occur if you use also use alcohol or other drugs that cause drowsiness or slow breathing.
  • Do not stop using aspirin and oxycodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.
  • Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.
  • Do not drink alcohol. Dangerous side effects or death could occur.
  • Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
  • Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to aspirin (such as aspirin, ibuprofen, ketoprofen, or naproxen).

Pregnancy and Lactation

  • If you use this medicine during pregnancy, your baby could be born with life-threatening withdrawal symptoms and may need medical treatment for several weeks. You should not use aspirin and oxycodone after 30 weeks of pregnancy.


  • Ask a doctor if it is safe to breastfeed. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.


Medically speaking, the term "myalgia" refers to what type of pain? See Answer

Health Solutions From Our Sponsors