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Last reviewed on RxList: 1/5/2017
Endrate Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 6/1/2016

Endrate (edetate disodium) is a chelating agent used to lower blood levels of calcium when they have become dangerously high. Endrate is also used to control heart rhythm disturbances caused by a heart medication called digitalis (digoxin, Lanoxin). The brand name Endrate is discontinued, but generic versions may be available. Common side effects of Endrate (edetate disodium) include:

  • nausea
  • vomiting
  • diarrhea
  • numbness or tingling (especially around your mouth)
  • headache, or
  • infusion site reactions (pain, redness, or swelling)

The recommended adult daily dosage of Endrate is 50 mg/kg of body weight to a maximum dose of 3 g in 24 hours. A suggested regimen includes five consecutive daily doses followed by two days without medication, with repeated courses as necessary to a total of 15 doses. Endrate may interact with other drugs. Tell your doctor all medications and supplements you use. Endrate may be harmful to a fetus. Tell your doctor if you are pregnant before you receive Endrate. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Our Endrate (edetate disodium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Endrate Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers at once if you have any of these serious side effects:

  • feeling like you might pass out; or
  • severe blistering, peeling, or red skin rash.

Less serious side effects include:

  • nausea, vomiting, diarrhea;
  • numbness or tingling (especially around your mouth);
  • headache; or
  • pain, redness, or swelling where the needle is placed.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Endrate (Edetate)

Endrate Professional Information


Gastrointestinal symptoms such as nausea, vomiting and diarrhea are fairly common following administration of this drug. Transient symptoms such as circumoral paresthesia, numbness and headache and a transient drop in systolic and diastolic blood pressure may occur. Thrombophlebitis, febrile reactions, hyperuricemia, anemia, exfoliative dermatitis and other toxic skin and mucous membrane reactions have been reported.

Nephrotoxicity and damage to the reticuloendothelial system with hemorrhagic tendencies have been reported with excessive dosages.

Read the entire FDA prescribing information for Endrate (Edetate)

Related Resources for Endrate

© Endrate Patient Information is supplied by Cerner Multum, Inc. and Endrate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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