Enlon Plus Side Effects Center

Last updated on RxList: 9/16/2019
Enlon Plus Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 9/16/2019

Enlon-Plus (edrophonium chloride and atropine sulfate) Injection is a combination drug containing a rapid acting acetylcholinesterase inhibitor, and an anticholinergic used as a reversal agent or antagonist of nondepolarizing neuromuscular blocking agents. Enlon-Plus is also used adjunctively in the treatment of respiratory depression caused by curare overdosage. Common side effects of Enlon-Plus include:

Dosages of Enlon-Plus Injection range from 0.05-0.1 mL/kg given slowly over 45 seconds to 1 minute at a point of at least 5% recovery of twitch response to neuromuscular stimulation (95% block). The dosage delivered is 0.5-1.0 mg/kg of edrophonium chloride and 0.007-0.014 mg/kg of atropine sulfate. Enlon-Plus may interact with muscle relaxants, anticholinesterase drugs, narcotics, or beta-blockers. Tell your doctor all medications and supplements you use. During pregnancy, Enlon-Plus should be used only if prescribed. Consult your doctor before breastfeeding.

Our Enlon-Plus (edrophonium chloride, USP and atropine sulfate) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Arrhythmias Frequency > 10%: junctional rhythm, bradycardia, tachycardia; Frequency 3-10%: first and second degree A-V block, P Wave changes, atrial premature contractions; Frequency 1-3%: third degree A-V block, ventricular premature contractions; Frequency less than 1%: 3 second RR interval.

Of the patients who experienced any arrhythmias, 85% had the onset within two minutes, 74% no longer had any arrhythmias after 10 minutes. Arrhythmias related to increased vagal tone, bradycardia, second and third degree heart block respond to treatment with 0.2-0.4 mg of atropine I.V. (Bigeminy or ventricular ectopy may be treated with lidocaine 50 mg I.V.).

Adverse experiences reported for anticholinesterase agents such as edrophonium chloride, but not observed in the 235 patients studied with ENLON-PLUS (edrophonium chloride, USP and atropine sulfate, USP) Injection:

Cardiovascular: Nonspecific EKG changes, fall in cardiac output leading to hypotension;

Respiratory: Increased tracheobronchial secretions, laryngospasm, bronchiolar constriction and respiratory muscle paralysis;

Neurologic: Convulsions, dysarthria, dysphonia, and dysphagia;

Gastrointestinal: Nausea, vomiting, increased peristalsis, increased gastric and intestinal secretions, diarrhea, abdominal cramps;

Musculoskeletal: Weakness and fasciculations;

Miscellaneous : Increased urinary frequency, diaphoresis, increased lacrimation, pupillary constriction, diplopia, and conjunctival hyperemia.

Untoward reactions to atropine sulfate generally are dose-related. Individual tolerance varies greatly but systemic doses of 0.5 to 10 mg are likely to produce the following effects, which were not observed in the 235 patients treated with ENLON-PLUS:

Neurologic: Speech disturbances and restlessness with asthenia;

Dermatological: Flushed, dry skin, formation of a scarlatiniform rash;

Miscellaneous: Dryness of the nose and mouth, thirst, blurred vision, photophobia, slight mydriasis. Atropine may produce fever through inhibition of heat loss by evaporation.

Read the entire FDA prescribing information for Enlon Plus (Edrophonium Chloride and Atropine Sulfate)


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© Enlon Plus Patient Information is supplied by Cerner Multum, Inc. and Enlon Plus Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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