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Last reviewed on RxList: 12/21/2020
Enskyce Side Effects Center

What Is Enskyce?

Enskyce (desogestrel and ethinyl estradiol tablets) are oral contraceptives indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception. Enskyce is available in generic form.

What Are Side Effects of Enskyce?

Common side effects of Enskyce include:

Cigarette smoking increases the risk of serious cardiovascular side effects from use of oral contraceptives such as Enskyce. Women who use oral contraceptives including Enskyce are strongly advised not to smoke.

Dosage for Enskyce

The dosage of Enskyce for the initial cycle of therapy is one light orange "active" tablet administered daily from the 1 day through the 21 day of the menstrual cycle, counting the first day of menstrual flow as "Day 1". Tablets are taken without interruption as follows: One light orange "active" tablet daily for 21 days, then one green "reminder" tablet daily for 7 days. After 28 tablets have been taken, a new course is started and a light orange "active" tablet is taken the next day.

What Drugs, Substances, or Supplements Interact with Enskyce?

Enskyce may interact with:

Tell your doctor all medications and supplements you use.

Enskyce During Pregnancy and Breastfeeding

Enskyce is not recommended for use during pregnancy. Small amounts of Enskyce pass into breast milk and may cause adverse reactions in nursing infants. Breastfeeding while using Enskyce is not recommended.

Additional Information

Our Enskyce (desogestrel and ethinyl estradiol tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Which of the following are methods for contraception? See Answer
Enskyce Professional Information


An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (see WARNINGS).

There is evidence of an association between the following conditions and the use of oral contraceptives

  • Mesenteric thrombosis
  • Retinal thrombosis

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:

  • Nausea
  • Vomiting
  • Gastrointestinal symptoms (such as abdominal cramps and bloating)
  • Breakthrough bleeding
  • Spotting
  • Change in menstrual flow
  • Amenorrhea
  • Temporary infertility after discontinuation of treatment
  • Edema
  • Melasma which may persist
  • Breast changes: tenderness, enlargement, secretion
  • Change in weight (increase or decrease)
  • Change in cervical erosion and secretion
  • Diminution in lactation when given immediately postpartum
  • Cholestatic jaundice
  • Migraine
  • Allergic reaction, including rash, urticaria, and angioedema
  • Mental depression
  • Reduced tolerance to carbohydrates
  • Vaginal candidiasis
  • Change in corneal curvature (steepening)
  • Intolerance to contact lenses

The following adverse reactions have been reported in users of oral contraceptives and a causal association has been neither confirmed nor refuted:

Read the entire FDA prescribing information for Enskyce (Desogestrel and Ethinyl Estradiol Tablets)


Choosing Your Birth Control Method See Slideshow
Related Resources for Enskyce

© Enskyce Patient Information is supplied by Cerner Multum, Inc. and Enskyce Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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