Enstilar Side Effects Center

Last updated on RxList: 11/6/2020
Enstilar Side Effects Center

What Is Enstilar?

Enstilar (calcipotriene and betamethasone dipropionate) Foam, 0.005%/0.064%, is a combination a vitamin D analog and a corticosteroid, indicated for the topical treatment of plaque psoriasis in patients 18 years of age and older.

What Are Side Effects of Enstilar?

Common side effects of Enstilar include:

  • application site reactions (irritation, redness, infected hair follicles, loss of skin color),
  • high blood calcium levels,
  • hives, and
  • worsening of psoriasis
  • Dosage for Enstilar

    Apply a dose of Enstilar Foam to affected area(s) once daily for up to 4 weeks.

    What Drugs, Substances, or Supplements Interact with Enstilar?

    Enstilar may interact with other drugs. Tell your doctor all medications and supplements you use.

    Enstilar During Pregnancy and Breastfeeding

    Tell your doctor if you are pregnant or plan to become pregnant before using Enstilar. Corticosteroids are known to cause harm to a fetus. Corticosteroids taken orally pass into breast milk; it is unknown if the topically applied medications in Enstilar would absorb systemically and pass into breast milk. Consult your doctor before breastfeeding.

    Additional Information

    Our Enstilar (calcipotriene and betamethasone dipropionate) Foam Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Psoriasis causes the top layer of skin cells to become inflamed and grow too quickly and flake off. See Answer
Enstilar Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • worsening of your skin condition;
  • redness, warmth, swelling, oozing, or severe irritation of any treated skin;
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • high calcium levels--confusion, tiredness, nausea, vomiting, loss of appetite, constipation, increased thirst or urination, weight loss;
  • high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor; or
  • possible signs of absorbing this medicine through your skin--weight gain (especially in your face or your upper back and torso), slow wound healing, thinning or discolored skin, increased body hair, muscle weakness, nausea, diarrhea, tiredness, mood changes, menstrual changes, sexual changes.

Common side effects may include:

  • skin irritation, rash, itching, redness, or hives;
  • redness or crusting around your hair follicles; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Types of Psoriasis: Medical Pictures and Treatments See Slideshow
Enstilar Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Clinical Trials Conducted In Subjects 18 Years And Oder With Psoriasis

The rates of adverse reactions described below were from three randomized, multicenter, vehicle and/or active-controlled clinical trials in adult subjects with plaque psoriasis [see Clinical Studies]. Subjects applied study product once daily for 4 weeks, and the median weekly dose of Enstilar Foam was 25 grams. Adverse reactions reported in <1% of adult subjects treated with Enstilar Foam included: application site irritation, application site pruritus, folliculitis, skin hypopigmentation, hypercalcemia, urticaria, and exacerbation of psoriasis.

Clinical Trials Conducted In Subjects 12 To 17 Years With Psoriasis

In one uncontrolled clinical trial, 106 subjects aged 12 to 17 years with plaque psoriasis of the scalp and body applied Enstilar Foam once daily for up to 4 weeks. The median weekly dose was 40 grams. Adverse reactions reported in <1% of adolescent subjects treated were acne, erythema, application site pain, and skin reactions [see Use In Specific Populations and CLINICAL PHARMACOLOGY].

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing reports for local adverse reactions to Enstilar Foam included application site pain/burning.

Postmarketing reports for local adverse reactions to topical corticosteroids included atrophy, striae, telangiectasia, dryness, perioral dermatitis, secondary infection, and miliaria.

Ophthalmic adverse reactions of cataracts, glaucoma, and increased intraocular pressure have been reported with the use of topical corticosteroids, including topical betamethasone products.

Read the entire FDA prescribing information for Enstilar (Calcipotriene and Betamethasone Dipropionate Foam, 0.005%/0.064%)

© Enstilar Patient Information is supplied by Cerner Multum, Inc. and Enstilar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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