Brand Names: Entereg
Generic Name: alvimopan (Pronunciation: AL vi MOE pan)
- What is alvimopan (Entereg)?
- What are the possible side effects of alvimopan (Entereg)?
- What is the most important information I should know about alvimopan (Entereg)?
- What should I discuss with my health care provider before I receive alvimopan (Entereg)?
- How is alvimopan given (Entereg)?
- What happens if I miss a dose (Entereg)?
- What happens if I overdose (Entereg)?
- What should I avoid while receiving alvimopan (Entereg)?
- What other drugs will affect alvimopan (Entereg)?
- Where can I get more information?
What is alvimopan (Entereg)?
Alvimopan reduces certain side effects of narcotic medications that are often used to prevent pain caused by surgery.
Narcotic medications can cause stomach pain, bloating, nausea, vomiting, and constipation. These side effects can delay recovery in patients undergoing gastrointestinal surgery.
Alvimopan works by preventing these side effects without reducing the pain-relieving effects of the narcotic.
Alvimopan is used to speed recovery of stomach and intestinal functions after a gastrointestinal surgery, and to prevent side effects caused by narcotic medications.
Alvimopan may also be used for other purposes not listed in this medication guide.
What are the possible side effects of alvimopan (Entereg)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers at once if you have a serious side effect such as:
- pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
- painful or difficult urination;
- urinating less than usual or not at all;
- confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.
Less serious side effects may include:
- stomach pain, indigestion;
- nausea, vomiting, diarrhea;
- constipation, gas; or
- back pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about alvimopan (Entereg)?
You should not use this medication if you are allergic to alvimopan, if you have severe liver or kidney disease, or if you have used a narcotic medication within the past 7 days. Narcotic medications are used for moderate to severe pain. Some prescription cough medications also contain narcotics.
Before you receive alvimopan, tell your doctor if you have liver or kidney disease.
Alvimopan is given only in a hospital for a short period of time.
Tell your caregivers right away if you have pale skin, easy bruising or bleeding, painful or difficult urination, or confusion with uneven heart rate, leg discomfort, muscle weakness or limp feeling, and increased urination.
What should I discuss with my health care provider before I receive alvimopan (Entereg)?
You should not use this medication if you are allergic to alvimopan, if you have severe liver or kidney disease, or if you have used a narcotic medication within the past 7 days, such as:
- codeine (Tylenol #3, Cheratuss, Guaiatuss);
- fentanyl (Abstral, Actiq, Fentora, Duragesic, Ionsys, Lazanda, Onsolis);
- hydrocodone (Lortab, Vicodin, Vicoprofen);
- hydromorphone (Dilaudid, Palladone);
- levorphanol (Levo-Dromoran);
- meperidine (Demerol);
- methadone (Methadose, Diskets, Dolophine);
- morphine (Avinza, Kadian, MS Contin, Oramorph);
- nalbuphine (Nubain);
- oxycodone (OxyContin, Combunox, Roxicodone, Percocet);
- oxymorphone (Numorphan, Opana); or
- pentazocine (Talwin).
To make sure you can safely take alvimopan, tell your doctor if you have any of these other conditions:
- liver disease; or
- kidney disease.
FDA pregnancy category B. Alvimopan is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether alvimopan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How is alvimopan given (Entereg)?
Alvimopan is given only in a hospital for a short period of time.
You will receive your first dose of alvimopan up to 5 hours before your surgery. You will then be given additional doses two times per day for up to 7 days.
What happens if I miss a dose (Entereg)?
Because you will receive alvimopan in a clinical setting, you are not likely to miss a dose.
What happens if I overdose (Entereg)?
Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
What should I avoid while receiving alvimopan (Entereg)?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
What other drugs will affect alvimopan (Entereg)?
Tell your doctor about all other medications you are using, including cold or allergy medicine.
It is especially important to tell your doctor if you have taken a narcotic medication within the past 7 days. Narcotic medications are used for moderate to severe pain. Some prescription cough medications also contain narcotics. You may be more likely to have unpleasant effects on your stomach if you have recently taken a narcotic medication.
There may be other drugs that can interact with alvimopan. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your doctor or pharmacist can provide more information about alvimopan
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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