Entresto vs. Ranexa

Are Entresto and Ranexa the Same Thing?

Entresto (sacubitril and valsartan) and Ranexa (ranolazine) are used to treat different kinds of heart problems.

Entresto is used to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.

Ranexa is prescribed to treat chronic angina.

Entresto and Ranexa belong to different drug classes. Entresto is a combination of a neprilysin inhibitor and an angiotensin II receptor blocker (ARB) and Ranexa is an anti-anginal medication.

Side effects of Entresto and Ranexa that are similar include dizziness.

Side effects of Entresto that are different from Ranexa include low blood pressure (hypotension), high blood potassium (hyperkalemia), cough, and kidney (renal) failure.

Side effects of Ranexa that are different from Entresto include spinning sensation, nausea, vomiting, stomach pain, constipation, headache, dry mouth, weakness, ringing in your ears, swelling in hands/ankles/feet, slow/fast/irregular heartbeats, tremors, blood in the urine, and shortness of breath.

Entresto may interact with angiotensin-converting-enzyme (ACE) inhibitors, other angiotensin receptor blockers (ARBs), potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), or lithium.

Ranexa may interact with grapefruit and grapefruit juice, antibiotics, antifungals, other medicines to treat heart disease, cholesterol-lowering medicines, diabetes medications, medicines to prevent organ transplant rejection, medicines to treat mental illness, or medicines to treat or prevent nausea and vomiting caused by chemotherapy or radiation.

What Are Possible Side Effects of Entresto?

Side effects of Entresto include:

  • low blood pressure (hypotension),
  • high blood potassium (hyperkalemia),
  • cough,
  • dizziness, and
  • kidney (renal) failure

What Are Possible Side Effects of Ranexa?

Common side effects of Ranexa include:

  • stomach upset,
  • nausea,
  • vomiting,
  • flushing (warmth, redness, or tingly feeling),
  • constipation,
  • headache,
  • confusion,
  • memory problems,
  • loss of balance or coordination,
  • blurred vision,
  • double vision,
  • eye redness,
  • lightheadedness,
  • dizziness,
  • spinning sensation,
  • drowsiness,
  • sleep problems (insomnia),
  • stuffy nose,
  • itching, or
  • rash, especially during the first few days as your body adjusts to this medication.

Tell your doctor if you experience serious side effects of Ranexa including:

What Is Entresto?

Entresto (sacubitril and valsartan) is a combination of a neprilysin inhibitor and an angiotensin II receptor blocker indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.

What Is Ranexa?

Ranexa (methocarbamol) is a muscle relaxant used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury.

IMAGES

See Images

What Drugs Interact With Entresto?

Entresto may interact with angiotensin-converting-enzyme (ACE) inhibitors, other angiotensin receptor blockers (ARBs), potassium-sparing diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), or lithium. Tell your doctor all medications and supplements you use. Entresto is not recommended for use during pregnancy. It may harm a fetus. Entresto is not recommended for use while breastfeeding.

What Drugs Interact With Ranexa?

Ranexa may interact with other medicines that can make you sleepy or slow your breathing (such as cold or allergy medicines, narcotic pain medicines, sleeping pills, muscle relaxers, and medicines for depression, seizure, anxiety), and heart or blood pressure medications. Ranexa may also interact with carbamazepine, diazepam, fluoxetine, olanzapine, fluvoxamine, omeprazole, rifampin, or medications to treat Parkinson's disease.

How Should Entresto Be Taken?

Entresto (ziprasidone HCl) is available as capsules and Entresto (ziprasidone mesylate) is available as an injection for intramuscular use.

Entresto Capsules should be administered at an initial daily dose of 20 mg twice daily with food. For intramuscular dosing, the recommended dose of Entresto is 10 mg to 20 mg administered as required up to a maximum dose of 40 mg per day.

How Should Ranexa Be Taken?

The recommended starting dose of Entresto is 49/51 mg twice-daily. Double the dose of Entresto after 2 to 4 weeks to the target maintenance dose of 97/103 mg twice-daily, as tolerated by the patient.

SLIDESHOW

Heart Disease: Symptoms, Signs, and Causes See Slideshow
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References


Novartis. Entresto Product Information.

https://www.entresto.com

Gilead Sciences, Inc. Ranexa Prescribing Information.

https://www.ranexahcp.com

Health Solutions From Our Sponsors