Enulose Side Effects Center

Last updated on RxList: 7/21/2021
Enulose Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Enulose?

Enulose (lactulose solution) is a synthetic disaccharide in solution form used to prevent and treat portal-systemic encephalopathy, including the stages of hepatic pre-coma and coma.

What Are Side Effects of Enulose?

Side effects of Enulose include:

  • abdominal distension,
  • gas (flatulence),
  • belching,
  • abdominal discomfort such as cramping,
  • nausea,
  • vomiting, and
  • diarrhea (with excessive dosage)

Dosage for Enulose

The usual adult, oral dosage of Enulose is 2 to 3 tablespoonfuls (30 to 45 ml, containing 20 g to 30 g of lactulose) three or four times daily. The dosage may be adjusted every day or two to produce 2 or 3 soft stools daily.

For rectal administration: three hundred ml of lactulose solution should be mixed with 700 mL of water or physiologic saline and retained for 30 to 60 minutes. Enulose enema may be repeated every 4 to 6 hours. If the enema is inadvertently evacuated too promptly, it may be repeated immediately.

Enulose In Children

Very little information on the use of Enulose in pediatric patients has been recorded.

What Drugs, Substances, or Supplements Interact with Enulose?

Enulose may interact with other medicines such as:

  • oral anti-infective therapy,
  • nonabsorbable antacids, and
  • other laxatives

Tell your doctor all medications and supplements you use.

Enulose During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Enulose; it is unknown how it would affect a fetus. It is not known if Enulose passes into breast milk. Because many drugs are excreted in breast milk, caution should be exercised when Enulose solution is administered to a breastfeeding woman.

Additional Information

Our Enulose (lactulose solution) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Enulose Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using lactulose and call your doctor at once if you have severe or ongoing diarrhea.

Common side effects may include:

  • bloating, gas;
  • stomach pain;
  • diarrhea; or
  • nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Enulose (Lactulose Solution)

QUESTION

Long-term heavy alcohol consumption can cause: See Answer
Enulose Professional Information

SIDE EFFECTS

Precise frequency data are not available.

Lactulose may produce gaseous distention with flatulence or belching and abdominal discomfort such as cramping in about 20% of patients. Excessive dosage can lead to diarrhea with potential complications such as loss of fluids, hypokalemia, and hypernatremia.

Nausea and vomiting have been reported.

To report SUSPECTED ADVERSE EVENTS, contact the FDA at 1-800-FDA-1088 or http://www.fda.gov/ for voluntary reporting of adverse reactions.

Read the entire FDA prescribing information for Enulose (Lactulose Solution)

© Enulose Patient Information is supplied by Cerner Multum, Inc. and Enulose Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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