Epifoam

Last updated on RxList: 7/22/2021
Epifoam Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Epifoam?

Epifoam (pramoxine hydrochloride and hydrocortisone acetate aerosol, foam) is a topical aerosol foam containing a corticosteroid used as an anti-inflammatory/anti-itch agent and a local anesthetic used to relieve inflammatory and itching manifestations of corticosteroid-responsive skin conditions (dermatoses).

What Are Side Effects of Epifoam?

Side effects of Epifoam include:

Dosage for Epifoam

Apply Epifoam to the affected area 3 to 4 times daily.

Epifoam In Children

Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing's syndrome than mature patients because of a larger skin surface area to body weight ratio.

HPA axis suppression, Cushing's syndrome, and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisone levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of pediatric patients.

What Drugs, Substances, or Supplements Interact with Epifoam?

Epifoam may interact with other medicines.

Tell your doctor all medications and supplements you use.

Epifoam During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Epifoam; it may harm a fetus. Tetracyclines such as Epifoam pass into breast milk. Breastfeeding while using Epifoam is not recommended because of the potential for serious adverse reactions in nursing infants.

Additional Information

Tell your doctor if you are pregnant or plan to become pregnant before using Epifoam: topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time. It is unknown if topical administration of corticosteroids such as that in Epifoam could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids pass into breast milk in quantities not likely to have a negative effect on the infant. Consult your doctor before breastfeeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Epifoam Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you show signs of absorbing too much of the medicine through your skin, such as:

  • blurred vision, eye pain, or seeing halos around lights;
  • mood changes;
  • sleep problems (insomnia);
  • high blood sugar (increased thirst or urination, hunger, dry mouth, fruity breath odor,weight loss);
  • weight gain, puffiness in your face; or
  • muscle weakness, feeling tired.

Stop using the medicine and call your doctor if you have rectal bleeding or severe irritation in any treated skin.

Common side effects may include:

  • mild redness or swelling of treated skin;
  • thinning of treated skin; or
  • numbness on areas where the medicine is accidentally applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Epifoam (Pramoxine Hydrochloride and Hydrocortisone Acetate Aerosol Foam)

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Epifoam Professional Information

SIDE EFFECTS

To report SUSPECTED ADVERSE REACTIONS, contact Meda Pharmaceuticals Inc. at 1-877-848-6610 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximately decreasing order of occurrence:

Burning, Itching, Irritation, Dryness, Folliculitis, Hypertrichosis, Acneiform eruptions, Hypopigmentation, Perioral dermatitis, Allergic contact dermatitis, Maceration of the skin, Secondary infection, Skin atrophy, Striae, Miliaria

DRUG INTERACTIONS

No Information Provided

Read the entire FDA prescribing information for Epifoam (Pramoxine Hydrochloride and Hydrocortisone Acetate Aerosol Foam)

© Epifoam Patient Information is supplied by Cerner Multum, Inc. and Epifoam Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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