Epinephrine Autoinjector Side Effects Center

Last updated on RxList: 7/7/2022
Epinephrine Autoinjector Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Epinephrine Autoinjector?

Epinephrine injection auto-injector contains a non-selective alpha and beta-adrenergic receptor agonist, indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis. Epinephrine injection is available in generic form.

What Are Side Effects of Epinephrine Autoinjector?

Common side effects of epinephrine injection include:

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Epinephrine Autoinjector

The dose of epinephrine for patients greater than or equal to 30 kg (66 lbs.) is 0.3 mg. The dose of epinephrine for patients 15 to 30 kg (33 lbs-66 lbs.) 0.15 mg.

What Drugs, Substances, or Supplements Interact with Epinephrine Autoinjector?

Epinephrine injection may interact with cardiac glycosides, diuretics, tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), levothyroxine sodium, certain antihistamines, beta-blockers, alpha- blockers, and ergot alkaloids. Tell your doctor all medications and supplements you use.

Epinephrine Autoinjector During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using epinephrine injection; it is unknown how it would affect a fetus. It is unknown if epinephrine passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Epinephrine Injection, Auto-Injector 0.3 Mg, 0.15 Mg, for Intramuscular or Subcutaneous Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Allergies can best be described as: See Answer
Epinephrine Autoinjector Consumer Information

Before using epinephrine, tell your doctor if any past use of this medicine caused an allergic reaction to get worse.

Call your doctor at once if you notice pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection.

Side effects may be more likely in older adults.

Common side effects may include:

  • breathing problems;
  • fast, irregular, or pounding heartbeats;
  • pale skin, sweating;
  • nausea and vomiting;
  • dizziness;
  • weakness or tremors;
  • headache; or
  • feeling restless, fearful, nervous, anxious, or excited.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Epinephrine Autoinjector (Epinephrine Injection)


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Epinephrine Autoinjector Professional Information


Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.

Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache, and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].

Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].

Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see WARNINGS AND PRECAUTIONS].

Angina may occur in patients with coronary artery disease [see WARNINGS AND PRECAUTIONS].

Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].

Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.

Lacerations, bent needles, and embedded needles have been reported when epinephrine injection, USP auto-injector has been injected into the thigh of young children who are uncooperative and kick or move during an injection [see WARNINGS AND PRECAUTIONS].

Injection into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection in the thigh [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Epinephrine Autoinjector (Epinephrine Injection)

© Epinephrine Autoinjector Patient Information is supplied by Cerner Multum, Inc. and Epinephrine Autoinjector Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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