Epipen Side Effects Center

Last updated on RxList: 2/4/2021
Epipen Side Effects Center

What Is Epipen?

Epipen (epinephrine) is a sympathomimetic catecholamine used for the treatment of emergency allergic reactions including anaphylaxis to stinging insects and biting insects, allergen immunotherapy, foods, drugs, diagnostics testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis.

What Are Side Effects of Epipen?

Side effects of Epipen include:

Tell your doctor if you have serious side effects of Epipen including:

  • increased breathing difficulty,
  • dangerously high blood pressure,
  • severe headache,
  • blurred vision,
  • buzzing in your ears,
  • confusion,
  • chest pain,
  • shortness of breath,
  • irregular heartbeats, or
  • seizure.

Dosage for Epipen

Epipen Auto-Injector (0.15 and 0.3mg strengths) health care professionals should ensure that the patient or caregiver understands the indications and use of these products. Inject Epipen intramuscularly or subcutaneously into the anterolateral aspect of the thigh, through clothing if necessary. Do not inject into the buttock.

What Drugs, Substances, or Supplements Interact with Epipen?

Epipen may interact with digoxin, diuretics (water pills), levothyroxine, chlorpheniramine or diphenhydramine (antihistamines that a commonly contained in cold, allergy, or over-the-counter sleep medications), antidepressants, beta-blockers, ergot medicines, heart rhythm medications, or MAO inhibitors. Tell your doctor all medications and supplements you use.

Epipen During Pregnancy and Breastfeeding

Epinephrine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Do not use Epipen without your doctor's advice if you are breastfeeding. Pediatric patients under 15 kg have more risk of developing adverse reactions with Epipen.

Additional Information

Our Epipen (epinephrine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Epipen Consumer Information

Before using epinephrine, tell your doctor if any past use of this medicine caused an allergic reaction to get worse.

Call your doctor at once if you notice pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection.

Side effects may be more likely in older adults.

Common side effects may include:

  • breathing problems;
  • fast, irregular, or pounding heartbeats;
  • pale skin, sweating;
  • nausea and vomiting;
  • dizziness;
  • weakness or tremors;
  • headache; or
  • feeling restless, fearful, nervous, anxious, or excited.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Epipen (Epinephrine Auto Injector)


Allergies can best be described as: See Answer
Epipen Professional Information


Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.

Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].

Cardiovascular Reactions

  • Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].
  • Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see WARNINGS AND PRECAUTIONS].
  • Angina may occur in patients with coronary artery disease [see WARNINGS AND PRECAUTIONS].
  • Rare cases of stress cardiomyopathy have been reported in patients treated with epinephrine.

Reactions From Accidental Injection And/Or Improper Technique

  • Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].
  • Adverse reactions experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.
  • Lacerations, bent needles, and embedded needles have been reported when EpiPen has been injected into the thigh of young children who are uncooperative and kick or move during the injection [see WARNING AND PRECAUTIONS].
  • Injection into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].
Skin And Soft Tissue Infections
  • Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection, including EpiPen, in the thigh [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Epipen (Epinephrine Auto Injector)

© Epipen Patient Information is supplied by Cerner Multum, Inc. and Epipen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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