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Last reviewed on RxList: 6/7/2016
Epipen Side Effects Center

Last reviewed on RxList 11/30/2016

Epipen (epinephrine) is a sympathomimetic catecholamine used for the treatment of emergency allergic reactions including anaphylaxis to stinging insects and biting insects, allergen immunotherapy, foods, drugs, diagnostics testing substances and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. Side effects of Epipen include:

Tell your doctor if you have serious side effects of Epipen including:

  • increased breathing difficulty,
  • dangerously high blood pressure,
  • severe headache,
  • blurred vision,
  • buzzing in your ears,
  • confusion,
  • chest pain,
  • shortness of breath,
  • irregular heartbeats, or
  • seizure.

Epipen Auto-Injector (0.15 and 0.3mg strengths) health care professionals should ensure that the patient or caregiver understands the indications and use of these products. Inject Epipen intramuscularly or subcutaneously into the anterolateral aspect of the thigh, through clothing if necessary. Do not inject into the buttock. Epipen may interact with digoxin, diuretics (water pills), levothyroxine, chlorpheniramine or diphenhydramine (antihistamines that a commonly contained in cold, allergy, or over-the-counter sleep medications), antidepressants, beta-blockers, ergot medicines, heart rhythm medications, or MAO inhibitors. Tell your doctor all medications and supplements you use. Epinephrine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Do not use Epipen without your doctor's advice if you are breastfeeding. Pediatric patients under 15 kg have more risk of developing adverse reactions with Epipen.

Our Epipen (epinephrine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Epipen Consumer Information

Before using epinephrine a second time, call your doctor if your first injection caused a serious side effect such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • sweating;
  • nausea and vomiting;
  • pale skin;
  • feeling short of breath;
  • dizziness;
  • weakness or tremors;
  • headache; or
  • feeling nervous or anxious.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Epipen (Epinephrine Auto Injector)

Epipen Professional Information


Due to the lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.

Common adverse reactions to s ystemi call y admi nistered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].

Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].

Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see WARNINGS AND PRECAUTIONS].

Angina may occur in patients with coronary artery disease [see WARNINGS AND PRECAUTIONS].

Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].

Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.

Lacerations, bent needles, and embedded needles have been reported when EpiPen has been injected into the thigh of young children who are uncooperative and kick or move during the injection [see WARNINGS AND PRECAUTIONS].

Injection into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported following epinephrine injection, including EpiPen, in the thigh [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Epipen (Epinephrine Auto Injector)

Related Resources for Epipen

Read the Epipen User Reviews »

© Epipen Patient Information is supplied by Cerner Multum, Inc. and Epipen Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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