Equagesic Side Effects Center

Last updated on RxList: 8/8/2022
Equagesic Side Effects Center

What Is Equagesic?

Equagesic (meprobamate and aspirin) is a combination tranquilizer and analgesic used as an adjunct in the short-term treatment of pain accompanied by tension and/or anxiety in patients with musculoskeletal disease. The brand name Equagesic is discontinued, but generic versions may be available.

What Are Side Effects of Equagesic?

Common side effects of Equagesic (meprobamate and aspirin) include:

Equagesic may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • wheezing,
  • shortness of breath,
  • tightness in your chest,
  • loss of hearing,
  • red or pink urine,
  • confusion,
  • diarrhea,
  • convulsions,
  • lightheadedness,
  • dizziness,
  • drowsiness,
  • fast or deep breathing,
  • hallucinations,
  • severe headache,
  • sweating,
  • nausea,
  • vomiting,
  • nervousness,
  • excitement,
  • ringing in your ears,
  • slow heartbeat,
  • slurred speech,
  • lack of coordination,
  • stomach pain,
  • fever,
  • uncontrolled muscle movements of the arms or hands,
  • increased thirst,
  • vision problems,
  • severe weakness,
  • mood or behavioral changes,
  • bloody or tarry stools,
  • skin rash,
  • itching,
  • sore throat,
  • unusual bleeding,
  • easy bruising,
  • unusual excitement,
  • vomiting blood, and
  • vomit that looks like coffee grounds

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Equagesic

The usual dosage of Equagesic is one or two tablets, each tablet containing meprobamate, 200 mg, and aspirin, 325 mg, orally 3 to 4 times daily as needed for the relief of pain when tension or anxiety is present.

What Drugs, Substances, or Supplements Interact with Equagesic?

Equagesic may interact with other drugs. Tell your doctor all medications and supplements you use. Equagesic is not recommended for use during pregnancy.

Equagesic During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or become pregnant during treatment. This drug passes into breast milk. Consult your doctor before breastfeeding. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Additional Information

Our Equagesic (meprobamate and aspirin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Equagesic Professional Information



Aspirin may cause epigastric discomfort, nausea, and vomiting. Hypersensitivity reactions, including urticaria, angioneurotic edema, purpura, asthma, and anaphylaxis, may rarely occur. Patients receiving large doses of salicylates may develop tinnitus.


Central Nervous System

Drowsiness, ataxia, dizziness, slurred speech, headache, vertigo, weakness, paresthesias, impairment of visual accommodation, euphoria, overstimulation, paradoxical excitement, fast EEG activity.


Nausea, vomiting, diarrhea.


Palpitation, tachycardia, various forms of arrhythmia, transient ECG changes, syncope, hypotensive crisis.

Allergic or Idiosyncratic

Milder reactions are characterized by an itchy, urticarial, or erythematous maculopapular rash which may be generalized or confined to the groin.

Other reactions have included leukopenia, acute nonthrombocytopenic purpura, petechiae, ecchymoses, eosinophilia, peripheral edema, adenopathy, fever, fixed-drug eruption with cross-reaction to carisoprodol, and cross-sensitivity between meprobamate/mebutamate and meprobamate/carbromal.

More severe hypersensitivity reactions, rarely reported, include hyperpyrexia, chills, angioneurotic edema, bronchospasm, oliguria, and anuria. Also, anaphylaxis, exfoliative dermatitis, stomatitis, and proctitis. Stevens-Johnson syndrome and bullous dermatitis have occurred.

Hematologic (see also Allergic or Idiosyncratic section above)

Agranulocytosis, aplastic anemia have been reported, although n o causal relationship has been established, and thrombocytopenic purpura.


Exacerbation of porphyric symptoms.

Read the entire FDA prescribing information for Equagesic (Meprobamate and Aspirin)


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© Equagesic Patient Information is supplied by Cerner Multum, Inc. and Equagesic Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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