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Last reviewed on RxList: 3/20/2017
Eryc Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 1/10/2016

Eryc (erythromycin) is a macrolide antibiotic used in the treatment of many different kinds of infections including skin infections, respiratory tract infections including pneumonia, sexually transmitted diseases, diphtheria, and whooping cough (pertussis). Eryc is available in generic form as erythromycin. Side effects of Eryc include nausea, vomiting, stomach pain or cramps, loss of appetite, diarrhea, skin rash or itching, dizziness, headache, feeling tired, or vaginal itching or discharge.

The usual adult dose of Eryc is 250 mg every 6 hours taken one hour before meals. Pediatric dosing of Eric is based on the child's age, body weight, and severity of infection. Many drugs can interact with Eryc, such as Parlodel (bromocriptine), Lanoxin (digoxin), Xanax (alprazolam), and Viagra (sildenafil). This list is not complete and there are many other drugs that can interact with Eryc. There are no known adverse effects of erythromycin in pregnancy, but controlled studies have not been carried out. Erythromycin is excreted in human milk, and caution should be exercised when Eryc is administered to a breastfeeding woman.

Our Eryc Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Eryc Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • hearing problems (rare); or
  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Serious side effects may be more likely in older adults, including hearing loss, or a life-threatening fast heart rate.

Common side effects may include:

  • mild diarrhea; or
  • nausea, vomiting, stomach pain, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Eryc (Erythromycin Delayed-Release)

Eryc Professional Information


The most frequent side effects of oral erythromycin preparations are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Symptoms of hepatitis, hepatic dysfunction and/or abnormal liver function test results may occur (see WARNINGS).

Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment (see WARNINGS).

Erythromycin has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsade de pointes (see WARNINGS).

Allergic reactions ranging from urticaria to anaphylaxis have occurred. Skin reactions ranging from mild eruptions to erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported rarely.

There have been reports of interstitial nephritis coincident with erythromycin use.

There have been reports of pancreatitis and convulsions.

There have been isolated reports of reversible hearing loss occurring chiefly in patients with renal insufficiency and in patients receiving high doses of erythromycin.

Read the entire FDA prescribing information for Eryc (Erythromycin Delayed-Release)

Related Resources for Eryc

Read the Eryc User Reviews »

© Eryc Patient Information is supplied by Cerner Multum, Inc. and Eryc Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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