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Erythromycin Ethylsuccinate

Last reviewed on RxList: 6/8/2017
Erythromycin Ethylsuccinate Side Effects Center

Last reviewed on RxList 12/9/2016

E.E.S. (erythromycin ethylsuccinate) is a macrolide antibiotic used to treat many different types of infections caused by bacteria. E.E.S. is available in generic form. Common side effects of E.E.S. (erythromycin ethylsuccinate) include:

Tell your doctor if you have serious side effects of E.E.S. (erythromycin ethylsuccinate) including:

  • signs of liver disease (such as persistent nausea or vomiting, yellowing eyes or skin, dark urine, severe stomach or abdominal pain),
  • unusual tiredness,
  • muscle weakness,
  • slurred speech,
  • blurred vision,
  • drooping eyelids, or
  • hearing loss.

The usual adult dose of erythromycin ethylsuccinate is 400 mg every 6 hours. Dosage may be increased up to 4 g per day according to the severity of the infection. The pediatric dose in mild to moderate infections is 30 to 50 mg/kg/day in equally divided doses every 6 hours. Erythromycin ethylsuccinate may interact with bromocriptine, cilostazol, cyclosporinem, digoxin, disopyramide, quinidine, sildenafil, tacrolimus, theophylline, verapamil, vinblastine, alprazolam or triazolam, blood thinners, carbamazepine, phenytoin, valproic acid, cholesterol-lowering medication, ergotamine, dihydroergotamine, or other antibiotics. Tell your doctor all medications you are taking. Erythromycin ethylsuccinate is not expected to be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Our E.E.S. (erythromycin ethylsuccinate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Erythromycin Ethylsuccinate Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • severe dizziness, fainting, fast or pounding heartbeats;
  • diarrhea that is watery or bloody;
  • hearing problems;
  • vomiting or fussiness after eating (in a child taking erythromycin);
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea, or stomach pain;
  • dizziness, headache, feeling tired;
  • vaginal itching or discharge; or
  • mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Erythromycin Ethylsuccinate (Erythromycin Ethylsuccinate)

Erythromycin Ethylsuccinate Professional Information


The most frequent side effects of oral erythromycin preparations are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Symptoms of hepatitis, hepatic dysfunction and/or abnormal liver function test results may occur. (See WARNINGS.)

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. (See WARNINGS.)

Erythromycin has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsades de pointes.

Allergic reactions ranging from urticaria to anaphylaxis have occurred. Skin reactions ranging from mild eruptions to erythema multiforme, Stevens- (erythromycin ethylsuccinate) Johnson syndrome, and toxic epidermal necrolysis have been reported rarely.

There have been rare reports of pancreatitis and convulsions.

There have been isolated reports of reversi (erythromycin ethylsuccinate) ble hearing loss occurring chiefly in patients with renal insufficiency and in patients receiving high doses of erythromycin.

Read the entire FDA prescribing information for Erythromycin Ethylsuccinate (Erythromycin Ethylsuccinate)

Related Resources for Erythromycin Ethylsuccinate

Read the Erythromycin Ethylsuccinate User Reviews »

© Erythromycin Ethylsuccinate Patient Information is supplied by Cerner Multum, Inc. and Erythromycin Ethylsuccinate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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