Erythromycin Ethylsuccinate

Last updated on RxList: 3/23/2021
Erythromycin Ethylsuccinate Side Effects Center

What Is E.E.S.?

E.E.S. (erythromycin ethylsuccinate) is a macrolide antibiotic used to treat many different types of infections caused by bacteria. E.E.S. is available in generic form.

What Are Side Effects of E.E.S.?

Common side effects of E.E.S. (erythromycin ethylsuccinate) include:

Tell your doctor if you have serious side effects of E.E.S. (erythromycin ethylsuccinate) including:

  • signs of liver disease (such as persistent nausea or vomiting, yellowing eyes or skin, dark urine, severe stomach or abdominal pain),
  • unusual tiredness,
  • muscle weakness,
  • slurred speech,
  • blurred vision,
  • drooping eyelids, or
  • hearing loss.

Dosage for E.E.S.

The usual adult dose of erythromycin ethylsuccinate is 400 mg every 6 hours. Dosage may be increased up to 4 g per day according to the severity of the infection. The pediatric dose in mild to moderate infections is 30 to 50 mg/kg/day in equally divided doses every 6 hours.

What Drugs, Substances, or Supplements Interact with E.E.S.?

Erythromycin ethylsuccinate may interact with bromocriptine, cilostazol, cyclosporinem, digoxin, disopyramide, quinidine, sildenafil, tacrolimus, theophylline, verapamil, vinblastine, alprazolam or triazolam, blood thinners, carbamazepine, phenytoin, valproic acid, cholesterol-lowering medication, ergotamine, dihydroergotamine, or other antibiotics. Tell your doctor all medications you are taking.

E.E.S. During Pregnancy and Breastfeeding

Erythromycin ethylsuccinate is not expected to be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our E.E.S. (erythromycin ethylsuccinate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Bowel regularity means a bowel movement every day. See Answer
Erythromycin Ethylsuccinate Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • a seizure;
  • hearing problems (rare);
  • pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting; or
  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, easy bruising or bleeding, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Serious side effects may be more likely in older adults, including hearing loss, or a life-threatening fast heart rate.

Call your doctor if a baby using this medicine is vomiting or irritable with feeding.

Common side effects may include:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • liver problems; or
  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Erythromycin Ethylsuccinate (Erythromycin Ethylsuccinate)


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Erythromycin Ethylsuccinate Professional Information


The most frequent side effects of oral erythromycin preparations are gastrointestinal and are dose-related. They include nausea, vomiting, abdominal pain, diarrhea and anorexia. Symptoms of hepatitis, hepatic dysfunction and/or abnormal liver function test results may occur. (See WARNINGS.)

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. (See WARNINGS.)

Erythromycin has been associated with QT prolongation and ventricular arrhythmias, including ventricular tachycardia and torsades de pointes.

Allergic reactions ranging from urticaria to anaphylaxis have occurred. Skin reactions ranging from mild eruptions to erythema multiforme, Stevens- (erythromycin ethylsuccinate) Johnson syndrome, and toxic epidermal necrolysis have been reported rarely.

There have been rare reports of pancreatitis and convulsions.

There have been isolated reports of reversi (erythromycin ethylsuccinate) ble hearing loss occurring chiefly in patients with renal insufficiency and in patients receiving high doses of erythromycin.

Read the entire FDA prescribing information for Erythromycin Ethylsuccinate (Erythromycin Ethylsuccinate)

© Erythromycin Ethylsuccinate Patient Information is supplied by Cerner Multum, Inc. and Erythromycin Ethylsuccinate Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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