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Last reviewed on RxList: 9/9/2016
Estrace Side Effects Center

Last reviewed on RxList 9/12/2016

Estrace (estradiol) is a female hormone (estrogen) used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination. Estrace is available in generic form. Common side effects of Estrace include:

The dosage range of Estrace is 2 to 4 g (marked on the applicator) daily for one or two weeks, then gradually reduced to one half initial dosage for a similar period. A maintenance dosage of 1 g, one to three times a week, may be used after restoration of the vaginal mucosa has been achieved. Estrace may interact with anticoagulants (blood thinners), thyroid medication, insulin or an oral diabetes medicine, glyburide, or tamoxifen. Tell your doctor all medications you are taking. Estrace must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately. This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Our Estrace (estradiol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Estrace Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using estradiol and call your doctor at once if you have a serious side effect such as:

  • unusual vaginal bleeding (especially if you are past menopause);
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, especially on one side of the body;
  • sudden severe headache, confusion, problems with vision, speech, or balance;
  • stabbing chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
  • pain, swelling, warmth, or redness in one or both legs;
  • nausea, vomiting, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless;
  • a lump in your breast;
  • feeling like you might pass out;
  • pain, swelling, or tenderness in your stomach; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • mild nausea, vomiting, bloating, stomach cramps;
  • breast pain, tenderness, or swelling;
  • freckles or darkening of facial skin;
  • loss of scalp hair;
  • vaginal itching or discharge; or
  • changes in your menstrual periods, break-through bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Estrace (Estradiol)

Estrace Professional Information



The following additional adverse reactions have been reported with estrogen and/or progestin therapy.

Genitourinary System

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting, dysmenorrhea
Increase in size of uterine leiomyomata
Vaginitis, including vaginal candidiasis
Change in amount of cervical secretion
Changes in cervical ectropion
Ovarian cancer; endometrial hyperplasia; endometrial cancer


Tenderness, enlargement, pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer


Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure


Nausea, vomiting
Abdominal cramps, bloating
Cholestatic jaundice
Increased incidence of gallbladder disease
Enlargement of hepatic hemangiomas


Chloasma or melasma that may persist when drug is discontinued
Erythema multiforme
Erythema nodosum
Hemorrhagic eruption
Loss of scalp hair
Pruritus, rash


Retinal vascular thrombosis
Steepening of corneal curvature
Intolerance to contact lenses

Central Nervous System

Headache, migraine, dizziness
Mental depression
Nervousness, mood disturbances, irritability
Exacerbation of epilepsy


Increase or decrease in weight
Reduced carbohydrate tolerance
Aggravation of porphyria
Arthralgias; leg cramps
Changes in libido
Anaphylactoid/anaphylactic reactions
Exacerbation of asthma
Increased triglycerides

Read the entire FDA prescribing information for Estrace (Estradiol)

Related Resources for Estrace

Read the Estrace User Reviews »

© Estrace Patient Information is supplied by Cerner Multum, Inc. and Estrace Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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