Estrace Side Effects Center

Last updated on RxList: 6/6/2022
Estrace Side Effects Center

What Is Estrace?

Estrace (estradiol) is a female hormone (estrogen) used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination. Estrace is available in generic form.

What Are Side Effects of Estrace?

Common side effects of Estrace include:

  • nausea,
  • vomiting,
  • bloating,
  • stomach cramps,
  • stomach upset,
  • breast tenderness/pain/swelling,
  • headache,
  • weight changes,
  • freckles or darkening of facial skin,
  • loss of scalp hair,
  • vaginal itching or discharge,
  • changes in your menstrual periods, or
  • break-through bleeding.

Dosage for Estrace

The dosage range of Estrace is 2 to 4 g (marked on the applicator) daily for one or two weeks, then gradually reduced to one half initial dosage for a similar period. A maintenance dosage of 1 g, one to three times a week, may be used after restoration of the vaginal mucosa has been achieved.

What Drugs, Substances, or Supplements Interact with Estrace?

Estrace may interact with anticoagulants (blood thinners), thyroid medication, insulin or an oral diabetes medicine, glyburide, or tamoxifen. Tell your doctor all medications you are taking.

Estrace During Pregnancy and Breastfeeding

Estrace must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately. This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Additional Information

Our Estrace (estradiol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Estrace Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • swelling or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes);
  • memory problems, confusion, unusual behavior;
  • unusual vaginal bleeding, pelvic pain;
  • a lump in your breast; or
  • high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects may include:

  • nausea, vomiting, diarrhea, stomach cramps;
  • mood changes, sleep problems (insomnia);
  • cold symptoms such as stuffy nose, sinus pain, sore throat;
  • weight gain;
  • headache, back pain;
  • breast pain;
  • thinning scalp hair; or
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer
Estrace Professional Information



The following additional adverse reactions have been reported with estrogen and/or progestin therapy.

Genitourinary System

Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting, dysmenorrhea
Increase in size of uterine leiomyomata
Vaginitis, including vaginal candidiasis
Change in amount of cervical secretion
Changes in cervical ectropion
Ovarian cancer; endometrial hyperplasia; endometrial cancer


Tenderness, enlargement, pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer


Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure


Nausea, vomiting
Abdominal cramps, bloating
Cholestatic jaundice
Increased incidence of gallbladder disease
Enlargement of hepatic hemangiomas


Chloasma or melasma that may persist when drug is discontinued
Erythema multiforme
Erythema nodosum
Hemorrhagic eruption
Loss of scalp hair
Pruritus, rash


Retinal vascular thrombosis
Steepening of corneal curvature
Intolerance to contact lenses

Central Nervous System

Headache, migraine, dizziness
Mental depression
Nervousness, mood disturbances, irritability
Exacerbation of epilepsy


Increase or decrease in weight
Reduced carbohydrate tolerance
Aggravation of porphyria
Arthralgias; leg cramps
Changes in libido
Anaphylactoid/anaphylactic reactions
Exacerbation of asthma
Increased triglycerides

Read the entire FDA prescribing information for Estrace (Estradiol)

© Estrace Patient Information is supplied by Cerner Multum, Inc. and Estrace Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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