Estraderm Side Effects Center

Last updated on RxList: 3/29/2021
Estraderm Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Estraderm?

Estraderm (estradiol) Transdermal System is a form of the female hormone estrogen, used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estraderm also reduces urgency or irritation of urination, and is used to treat ovarian disorders, infertility, and abnormal vaginal bleeding. Some estradiol skin patches are used to prevent postmenopausal osteoporosis.

What Are Side Effects of Estraderm?

Common side effects of Estraderm include:

  • skin redness/irritation at the application site
  • nausea/vomiting
  • upset stomach
  • bloating
  • constipation
  • breast swelling or tenderness
  • nipple discharge
  • headache
  • weight changes
  • acne
  • skin color changes
  • increased facial hair
  • thinning scalp hair
  • headache
  • back pain
  • joint pain
  • cold symptoms (stuffy nose, sneezing, sinus pain, sore throat
  • changes in your menstrual periods, and
  • break-through bleeding

Dosage for Estraderm

Place the adhesive side of the Estraderm system on a clean, dry area of the skin on the trunk of the body (including the buttocks and abdomen), and replace twice weekly. Select a site that is not exposed to sunlight. Do not apply Estraderm to the breasts.

What Drugs, Substances, or Supplements Interact with Estraderm?

Estraderm may interact with carbamazepine, phenobarbital, St. John's wort, blood thinners, antibiotics, antifungal medications, or ritonavir and other HIV/AIDS medications. Tell your doctor all medications and supplements you use.

Estraderm During Pregnancy and Breastfeeding

Estraderm must not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor. Estraderm passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breastfeeding.

Additional Information

Our Estraderm (estradiol) Transdermal System Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What Is Osteoporosis? Treatment, Symptoms, Medication See Slideshow
Estraderm Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Remove the skin patch and call your doctor at once if you have:

  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears, anxiety, nosebleed;
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs;
  • swelling or tenderness in your stomach;
  • jaundice (yellowing of the skin or eyes);
  • unusual vaginal bleeding, pelvic pain;
  • a breast lump;
  • memory problems, confusion, unusual behavior; or
  • high levels of calcium in your blood--nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy.

Common side effects may include:

  • headache, back pain;
  • stuffy nose, sinus pain, sore throat;
  • vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding;
  • bloating, stomach cramps, nausea, vomiting;
  • breast pain;
  • redness or irritation where the patch was worn;
  • thinning scalp hair; or
  • fluid retention (swelling, rapid weight gain).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Estraderm (Estradiol Transdermal)


If menopause occurs in a woman younger than ___ years, it is considered to be premature. See Answer
Estraderm Professional Information



The most commonly reported adverse reaction to Estraderm (estradiol transdermal) in clinical trials was redness and irritation at the application site. This occurred in about 17% of the women treated and caused approximately 2% to discontinue therapy. Reports of rash have been rare. There have also been rare reports of severe systemic allergic reactions.

The following additional adverse reactions have been reported with estrogens:

  1. Genitourinary system. Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding; spotting; dysmenorrheal, increase in size of uterine leiomyomata; vaginitis, including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer.
  2. Breasts. Tenderness, enlargement, pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer.
  3. Cardiovascular. Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure.
  4. Gastrointestinal. Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gall bladder disease; pancreatitis, enlargement of hepatic hemangiomas.
  5. Skin. Chloasma or melasma, which may persist when drug is discontinued; erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash.
  6. Eyes. Retinal vascular thrombosis; intolerance to contact lenses.
  7. Central nervous system. Headache; migraine; dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia.
  8. Miscellaneous. Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; arthralgias; leg cramps; changes in libido; anaphylactoid/anaphylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.

Read the entire FDA prescribing information for Estraderm (Estradiol Transdermal)

© Estraderm Patient Information is supplied by Cerner Multum, Inc. and Estraderm Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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