What Is Estrostep?
Estrostep 21 (norethindrone acetate and ethinyl estradiol) is an oral contraceptive that contains a combination of female hormones used to prevent pregnancy. Estrostep 21 is also used to treat severe acne. Estrostep 21 may be available in generic form.
What Are Side Effects of Estrostep?
Common side effects of Estrostep 21 include:
- stomach cramping/bloating,
- vaginal discomfort/irritation,
- increased vaginal fluids, or
- breast tenderness/enlargement
Acne may improve or get worse. Other side effects of Estrostep 21 include:
- vaginal bleeding between periods (spotting)
- missed/irregular periods, especially during the first few months of use
Dosage for Estrostep
The dose of Estrostep 21 is 1 tablet taken daily for 21 consecutive days. Wait 7 days to start the next pack. You will probably have your period during that week. Be sure that no more than 7 days pass between 21-day packs.
What Drugs, Substances, or Supplements Interact with Estrostep?
Estrostep 21 may interact with acetaminophen, ascorbic acid (vitamin C), prednisolone, theophylline, St. John's wort, antibiotics, seizure medications, barbiturates, or HIV or AIDS medications. Tell your doctor all medications and supplements you use. Estrostep 21 must not be used during pregnancy.
Estrostep During Pregnancy or Breastfeeding
If you have just given birth or had a pregnancy loss/abortion after the first 3 months, consult your doctor and find out when it is safe to use birth control containing estrogen. Estrostep 21 passes into breast milk. Consult your doctor before breastfeeding.
Our Estrostep 21 (norethindrone acetate and ethinyl estradiol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
An increased risk of the following serious adverse reactions has been associated with the use of oral contraceptives (see WARNINGS section):
- Arterial thromboembolism
- Pulmonary embolism
- Myocardial infarction
- Cerebral hemorrhage
- Cerebral thrombosis
- Gallbladder disease
- Hepatic adenomas or benign liver tumors
There is evidence of an association between the following conditions and the use of oral contraceptives, although additional confirmatory studies are needed:
- Mesenteric thrombosis
- Retinal thrombosis
The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:
- Gastrointestinal symptoms (such as abdominal cramps and bloating)
- Breakthrough bleeding
- Change in menstrual flow
- Temporary infertility after discontinuation of treatment
- Melasma which may persist
- Breast changes: tenderness, enlargement, secretion
- Change in weight (increase or decrease)
- Change in cervical erosion and secretion
- Diminution in lactation when given immediately postpartum
- Cholestatic jaundice
- Rash (allergic)
- Mental depression
- Reduced tolerance to carbohydrates
- Vaginal candidiasis
- Change in corneal curvature (steepening)
- Intolerance to contact lenses
The following adverse reactions have been reported in users of oral contraceptives and the association has been neither confirmed nor refuted:
- Pre-menstrual syndrome
- Changes in appetite
- Cystitis-like syndrome
- Loss of scalp hair
- Erythema multiforme
- Erythema nodosum
- Hemorrhagic eruption
- Impaired renal function
- Hemolytic uremic syndrome
- Budd-Chiari syndrome
- Changes in libido
Read the entire FDA prescribing information for Estrostep (Norethindrone Acetate and Ethinyl Estradiol)
© Estrostep Patient Information is supplied by Cerner Multum, Inc. and Estrostep Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.
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