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Last reviewed on RxList: 12/5/2016
Ethrane Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 2/18/2016

Ethrane (enflurane) Liquid For Inhalation is a general inhalation anesthetic drug used for induction and maintenance of general anesthesia. Ethrane is available in generic form. Common side effects of Ethrane include elevated body temperature, seizures, low blood pressure, slow or shallow breathing, low blood oxygen, heart arrhythmias, shivering, chills, nausea, vomiting, or liver damage.

Ethrane is delivered from a vaporizer during anesthesia, and the dose is individualized for each patient. Ethrane may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Ethrane should be used only if prescribed. Tell your doctor if you are pregnant. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Ethrane (enflurane) Liquid For Inhalation Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ethrane Professional Information


  1. Malignant hyperthermia (see WARNINGS).
  2. Motor activity exemplified by movements of various muscle groups and/or seizures may be encountered with deep levels of ETHRANE (enflurane, USP) anesthesia, or light levels with hypocapnia.
  3. Hypotension, respiratory depression, and hypoxia have been reported.
  4. Arrhythmias, shivering, nausea and vomiting have been reported.
  5. Elevation of the white blood count has been observed.
  6. Mild, moderate and severe liver injury, including hepatic failure, may rarely follow anesthesia with enflurane. Serum transaminases may be increased and histologic evidence of injury may be found. The histologic changes are neither unique nor consistent. In several of these cases, it has not been possible to exclude enflurane as the cause or as a contributing cause to liver injury. The incidence of unexplained hepatotoxicity following the administration of enflurane is unknown, but it appears to be rare and not dose related.

ETHRANE (enflurane, USP) has also been associated with perioperative hyperkalemia (see WARNINGS).

Post-Marketing Events

The following adverse events have been identified during post-approval use of ETHRANE (enflurane, USP). Due to the spontaneous nature of these reports, the actual incidence and relationship of ETHRANE (enflurane, USP) to these events cannot be established with certainty.

Cardiac Disorders: Cardiac arrest

Hepatobiliary Disorders: Hepatic necrosis, Hepatic failure

Read the entire FDA prescribing information for Ethrane (Enflurane)

Related Resources for Ethrane

© Ethrane Patient Information is supplied by Cerner Multum, Inc. and Ethrane Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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