Ethyl Chloride

Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 11/5/2021

Drug Summary

What Is Ethyl Chloride?

Ethyl Chloride Topical Anesthetic is a vapocoolant (skin refrigerant) used to prevent pain caused by injections and minor surgical procedures. Ethyl Chloride Topical Anesthetic is also used for the temporary relief of minor sports injuries. The brand name of this medication is discontinued, but generic versions may be available.

What Are Side Effects of Ethyl Chloride?

Side effects are not common with Ethyl Chloride Topical Anesthetic; consult your doctor. Tell your doctor if you experience an unlikely but serious side effects of Ethyl Chloride Topical Anesthetic including:

  • lasting changes in skin color,
  • pain as skin is thawing,
  • infection at the application site,
  • delayed wound healing,
  • a serious allergic reaction (rash, itching, or swelling, especially of the face/tongue/throat),
  • hives,
  • dizziness,
  • trouble breathing,
  • decreased urination or changes in the amount of urine,
  • dark urine,
  • stomach or abdominal pain,
  • persistent nausea or vomiting,
  • unusual tiredness, or
  • yellowing of the skin or eyes (jaundice).

Dosage for Ethyl Chloride

Spray the target area with Gebauer's Ethyl Chloride continuously for 3 to 7 seconds (aerosol can 4 to 10 seconds) from a distance of 3 to 9 inches (8-23 cm).

What Drugs, Substances, or Supplements Interact with Ethyl Chloride?

Ethyl chloride may interact with other drugs. Tell your doctor all medications and supplements you use.

Ethyl Chloride During Pregnancy or Breastfeeding

During pregnancy, ethyl chloride should be used only if prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Ethyl Chloride Topical Anesthetic Skin Refrigerant Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Drug Description


Gebauer's Ethyl Chloride® is a vapocoolant (skin refrigerant) intended for topical application.

Product Identification

Trade Name / Synonym: Gebauer's Ethyl Chloride® Revision Date: May 19, 2005
Chemical Name / Synonyms: Ethyl Chloride, Chloroethane, Hydrochloric Ether Chemical Family: Halogenated Hydrocarbon
Formula: C2H5Cl Molecular Weight: 64.52

Source: Material Safety Data Sheet
4444 E. 153rd STREET
1-800-321-9348 toll free or (216) 581-3030
FAX (216) 581-4970; WEBSITE:
AFTER HOURS EMERGENCY: CHEMTREC (800) 424-9300 or 703-527-3887

Indications & Dosage


Gebauer's Ethyl Chloride is a vapocoolant (skin refrigerant) intended for topical application to control pain associated with injections, starting IV's and venipuncture, minor surgical procedures (such as lancing boils or incision and drainage of small abscesses), and the temporary relief of minor sports injuries. The medium and fine streams are also intended for use as a counterirritant in the management of myofascial pain, restricted motion, and muscle tension.


DIRECTIONS FOR USE: To apply Gebauer's Ethyl Chloride from the amber bottle, hold the bottle inverted while spraying. Open the dispenseal spring valve completely allowing the Ethyl Chloride to flow from the bottle. To apply Gebauer's Ethyl Chloride from the aerosol can, hold can upright over the treatment area and depress the valve completely allowing Gebauer's Ethyl Chloride to spray from the can.

  1. PRE-INJECTION ANESTHESIA: Prepare the syringe. Swab the treatment area with an antiseptic. Amber bottle -spray the target area with Gebauer's Ethyl Chloride continuously for 3 to 7 seconds (aerosol can 4 to 10 seconds) from a distance of 3 to 9 inches (8-23 cm). Spray the area until the skin just turns white; do not frost the skin. With skin taut, quickly introduce the needle. Follow these directions for other types of needle insertion procedures such as starting IV's and venipuncture.
  2. TOPICAL ANESTHESIA IN MINOR SURGERY: Clean the operative site with a suitable antiseptic. Apply petrolatum to protect the adjacent area. Amber bottle - spray the target area with Gebauer's Ethyl Chloride continuously for 3 to 7 seconds (aerosol can 4 to 10 seconds) from a distance of 3 to 9 inches (8-23 cm). Spray the area until the skin just turns white; do not frost the skin. Promptly make incision. The anesthetic action of Gebauer's Ethyl Chloride lasts a few seconds to a minute.
  3. TEMPORARY RELIEF OF MINOR SPORTS INJURIES: The pain of bruises, contusions, swelling, and minor sprains may be controlled with Gebauer's Ethyl Chloride. The amount of cooling depends on the dosage. Dosage varies with duration of application. The smallest dose needed to produce the desired effect should be used. The anesthetic effect of ethyl chloride rarely lasts more than a few seconds to a minute.
    This time interval is usually sufficient to help reduce or relieve the initial trauma of the injury. Determine the extent of the injury (fracture, sprain, etc.). Amber bottle - spray the affected area from a distance of 3 to 9 inches (8-23 cm) for 3 to 7 seconds (aerosol can 4 to 10 seconds) until the skin just turns white; do not frost the skin. Avoid spraying the skin beyond this state. Use as you would ice.
  4. SPRAY AND STRETCH TECHNIQUE FOR MYOFASCIAL PAIN: Gebauer's Ethyl Chloride may be used as a counterirritant in the management of myofascial pain, restricted motion and muscle tension. Clinical conditions that may respond to Gebauer's Ethyl Chloride include low back pain (due to tight muscles), acute stiff neck, torticollis, acute bursitis of the shoulder, tight hamstrings, sprained ankle, tight masseter muscles and referred pains due to irritated trigger points. Relief of pain facilitates early mobilization and restoration of muscle function. The Spray and Stretch Technique is a therapeutic system that involves three states: Evaluation, Spraying, and Stretching. The therapeutic value of the Spray and Stretch Technique is most effective when the practitioner has mastered all of the stages and applies them in the proper sequence.

a. Evaluation

If the patient has been evaluated to have pain caused by an active, irritated trigger point then proceed to Step b.

b. Spraying

  1. Have the patient assume a comfortable position.
  2. Take precautions to cover the patient's eyes, nose and mouth if spraying near the face.
  3. Hold the bottle inverted. (Hold the can upright.) From a distance of 12 to 18 inches (30-46 cm) aim the stream so that it meets the skin at an acute angle to lessen the shock of impact.
  4. Direct the spray in parallel sweeps 0.5 to 1 inch (1.5-2 cm) apart at the rate of approximately 4 inches/second (10 cm/second). Continue until the entire muscle has been covered. The number of sweeps is determined by the size of the muscle. The spray should be applied from the muscle attachment over the trigger point, through and over the reference zone.

c. Stretching

Passively stretch the muscle during spray application. Gradually increase the force with successive sweeps. As the muscle relaxes, smoothly take up the slack by establishing a new stretch length. It is necessary to reach the full normal length of the muscle to completely inactivate the trigger point and relieve the pain. Rewarm the muscle. If necessary, repeat the procedure. Apply moist heat for 10 to 15 minutes following treatment. For lasting benefit, eliminate any factors that perpetuate the trigger mechanism.


CONTENTS: Ethyl chloride

STORAGE: Contents under pressure. Store in a cool place. Do not store above 120°F (50°C). Do not use near fire or flame or place on hot surfaces.

DISPOSAL: Dispose of in accordance with local, state, and national regulations.

For more information about this product contact Gebauer Company.To order Gebauer’s Ethyl Chloride, ask for:

  • Fine Stream Spray - 3.5 oz. Glass Bottle - P/N 0386-001-04
  • Medium Stream Spray - 3.5 oz. Glass Bottle - P/N 0386-001-03
  • Mist Spray - 3.5 oz. Can - P/N 0386-0001-02
  • Medium Stream Spray - 3.5 oz. Can - P/N 0386-001-06

Call for a distributor near you. 800-321-9348. FDA revision date: n/a

Side Effects & Drug Interactions


Cutaneous sensitization may occur, but appears to be extremely rare. Freezing can occasionally alter skin pigmentation.


No information provided

Warnings & Precautions


For external use only. Do not spray in the eyes. Skin absorption of ethyl chloride can occur; no cases of chronic poisoning have been reported. Ethyl chloride is known as a liver and kidney toxin; long-term exposure may cause liver or kidney damage.

WARNING: This product contains a chemical known to the State of California to cause cancer.



Do not spray in eyes. Inhalation of ethyl chloride should be avoided as it may produce narcotic and general anesthetic effects, and may produce deep anesthesia or fatal coma with respiratory or cardiac arrest. Ethyl chloride is FLAMMABLE and should never be used in the presence of an open flame or electrical cautery equipment. When used to produce local freezing of tissues, adjacent skin areas should be protected by an application of petrolatum. The thawing process may be painful, and freezing may lower local resistance to infection and delay healing.

Overdose & Contraindications


No information provided


Ethyl chloride is contraindicated in individuals with a history of hypersensitivity to it.

Clinical Pharmacology


No information provided

Medication Guide


No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

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