Eucrisa Side Effects Center

Last updated on RxList: 8/1/2022
Eucrisa Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Eucrisa?

Eucrisa (crisaborole) ointment, 2%, for topical use is a phosphodiesterase 4 inhibitor indicated for topical treatment of mild to moderate atopic dermatitis in patients 2 years of age and older.

What Are Side Effects of Eucrisa?

Common side effects of Eucrisa include application site pain.

  • hives,
  • itching,
  • swelling,
  • redness,
  • severe dizziness, and
  • trouble breathing

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Eucrisa

Apply a thin layer dose of Eucrisa twice daily to affected areas.

What Drugs, Substances, or Supplements Interact with Eucrisa?

Eucrisa may interact with other drugs. Tell your doctor all medications and supplements you use.

Eucrisa During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Eucrisa; it is unknown if it would affect a fetus. It is unknown if Eucrisa passes into breast milk or how it will affect a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Eucrisa (crisaborole) ointment, 2%, for topical use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Eucrisa Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin redness or swelling; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe itching, redness, or swelling of the skin where the medicine was applied.

Common side effects may include:

  • pain, burning, or stinging where the medicine was applied.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Eucrisa (crisaborole)


Eczema (also atopic eczema or atopic dermatitis) is a general medical term for many types of skin inflammation. See Answer
Eucrisa Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In two double-blind, vehicle-controlled clinical trials (Trial 1 and Trial 2), 1012 subjects 2 to 79 years of age with mild to moderate atopic dermatitis were treated with EUCRISA twice daily for 4 weeks. The adverse reaction reported by ≥1% of EUCRISA-treated subjects is listed in Table 1.

Table 1: Adverse Reaction Occurring in ≥1% of Subjects in Atopic Dermatitis Trials through Week 4

Adverse ReactionEUCRISA
n (%)
n (%)
Application site paina45 (4)6 (1)
a Refers to skin sensations such as burning or stinging.

Less common (<1%) adverse reactions in subjects treated with EUCRISA included contact urticaria [see WARNINGS AND PRECAUTIONS].

Postmarketing Experience

The following adverse reactions have been identified during postapproval use of EUCRISA. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure:

Skin and Subcutaneous: allergic contact dermatitis.

Read the entire FDA prescribing information for Eucrisa (crisaborole)

© Eucrisa Patient Information is supplied by Cerner Multum, Inc. and Eucrisa Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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