Evekeo Side Effects Center

Last updated on RxList: 2/10/2021
Evekeo Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Evekeo?

Evekeo (amphetamine sulfate tablets) is a central nervous system stimulant used to treat a sleep disorder called narcolepsy, and to help increase attention and decrease impulsiveness and hyperactivity in patients with ADHD. Evekeo should be used as part of a total treatment program for ADHD that may include counseling or other therapies. Evekeo may also be used as part of a short-term, weight reduction program to treat exogenous obesity.

What Are Side Effects of Evekeo?

Common side effects of Evekeo include:

Dosage for Evekeo

The usual dose of Evekeo to treat narcolepsy is 5 to 60 mg per day in divided doses. The usual starting dose of Evekeo to treat ADHD in children from 3 to 5 years of age is 2.5 mg daily; in children 6 years of age or older, start with 5 mg once or twice daily. The usual dose of Evekeo to treat exogenous obesity is up to 30 mg daily, taken in divided doses of 5 to 10 mg, 30 to 60 minutes before meals.

What Drugs, Substances, or Supplements Interact with Evekeo?

Evekeo may interact with stomach acid medicines, antidepressants including MAOIs, anti-psychotic medicines, lithium, cold or allergy medicines that contain decongestants, blood pressure medicines, narcotics, seizure medicines, or blood thinner medicines. Tell your doctor all medications and supplements you or your child use.

Evekeo During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or become pregnant while taking Evekeo. It is unknown if Evekeo would harm a fetus. Evekeo passes into breast milk and can harm a nursing baby. Breastfeeding while taking Evekeo is not recommended. Withdrawal symptoms may occur if you suddenly stop taking Evekeo.

Additional Information

Our Evekeo (amphetamine sulfate tablets) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


ADHD Symptoms in Children See Slideshow
Evekeo Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • signs of heart problems--chest pain, trouble breathing, feeling like you might pass out;
  • signs of psychosis--hallucinations (seeing or hearing things that are not real), new behavior problems, aggression, hostility, paranoia;
  • signs of circulation problems--numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
  • a seizure (convulsions);
  • muscle twitches (tics);
  • pain or burning when you urinate; or
  • changes in your vision.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Amphetamine can affect growth. Tell your doctor if your child is not growing at a normal rate.

Common side effects may include:

  • increased heart rate;
  • mood changes, anxiety, feeling restless or nervous;
  • trouble sleeping;
  • dry mouth, stomach pain, nausea, vomiting, diarrhea, constipation;
  • loss of appetite, weight loss;
  • painful urination;
  • sexual problems, impotence;
  • headache, dizziness;
  • fever, weakness; or
  • itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Evekeo (Amphetamine Sulfate Tablets, USP)


The abbreviated term ADHD denotes the condition commonly known as: See Answer
Evekeo Professional Information



Palpitations, tachycardia, elevation of blood pressure. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System

Psychotic episodes at recommended doses (rare), overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics and Tourette's syndrome.


Dryness of the mouth, unpleasant taste, diarrhea, constipation and other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects when amphetamines are used for other than the anorectic effect.




Impotence, changes in libido, and frequent or prolonged erections.



Drug Abuse And Dependence

Evekeo is a Schedule II controlled substance. Amphetamines have been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to many times the recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with amphetamines include severe dermatosis, marked insomnia, irritability, hyperactivity and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia. This is rare with oral amphetamines.

Read the entire FDA prescribing information for Evekeo (Amphetamine Sulfate Tablets, USP)

© Evekeo Patient Information is supplied by Cerner Multum, Inc. and Evekeo Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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