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Evening Primrose Oil

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Are there any interactions with medications?



Lopinavir/Ritonavir (Kaletra)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Lopinavir / ritonavir (Kaletra) is changed and broken down by the body. Evening primrose might decrease how quickly the body breaks down lopinavir / ritonavir (Kaletra). Taking evening primrose along with lopinavir / ritonavir (Kaletra) might increase the levels and effects of lopinavir / ritonavir (Kaletra).



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Evening primrose contains GLA (gamma-linolenic acid), which might slow blood clotting. Taking evening primrose along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), and naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



Medications used during surgery (Anesthesia)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Evening primrose might interact with medications used during surgery. One person who was taking evening primrose and other medications had a seizure during surgery. But there isn't enough information to know if evening primrose or the other medications caused the seizure. Be sure to tell your doctor what natural products you are taking before having surgery. To be on the safe side, you should stop taking evening primrose at least 2 weeks before surgery.



Phenothiazines
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Taking evening primrose with phenothiazines might increase the risk of having a seizure in some people.

Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others.



Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Evening primrose might decrease how quickly the liver breaks down some medications. Taking evening primrose along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking evening primrose, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and warfarin (Coumadin).



Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Some medications are changed and broken down by the liver. Evening primrose might decrease how quickly the liver breaks down some medications. Taking evening primrose along with some medications that are changed by the liver might increase the effects and side effects of these medications. Before taking evening primrose, talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications changed by the liver include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and others.

Dosing considerations for Evening Primrose.

The appropriate dose of evening primrose depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for evening primrose. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Therapeutic Research Faculty copyright

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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