Evista vs. Prolia

• Are Evista and Prolia the Same Thing?
• What Are Possible Side Effects of Evista?
• What Are Possible Side Effects of Prolia?
• What is Evista?
• What is Prolia?
• What Drugs Interact with Evista?
• What Drugs Interact with Prolia?
• How Should Evista Be Taken?
• How Should Prolia Be Taken?

Prolia (denosumab) and Evista (raloxifene hydrochloride) are used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Evista is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are otherwise at risk of invasive breast cancer.

Prolia is a monoclonal antibody and Evista is an estrogen agonist/antagonist.

Common side effects of Evista include:

• hot flashes,
• increased sweating,
• headache,
• dizziness,
• spinning sensation,
• leg cramps or leg pain,
• joint pain,
• nausea,
• vomiting,
• stomach pain, or
• runny or stuffy nose.
• Evista may infrequently cause stroke or serious blood clots to form in the legs, lungs, or eyes.

Seek medical attention if you have unlikely but serious side effects of Evista including:

• leg swelling or pain,
• trouble breathing,
• chest pain,
• sudden vision changes,
• severe headache,
• weakness on one side of the body, or
• confusion.

Common side effects of Prolia include:

• low calcium levels (especially if you have kidney problems),
• weakness,
• constipation,
• back pain,
• muscle pain,
• pain in your arms and legs,
• anemia,
• diarrhea, or
• skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps).

You may also be more likely to get a serious infection, such as a skin, ear, stomach/gut, or bladder infection while taking Prolia. Tell your doctor if you develop signs of infection, such as:

• fever/chills, night sweats,
• red/swollen/tender/warm skin (with or without pus),
• severe stomach or abdominal pain,
• ear pain or drainage, trouble hearing,
• frequent/painful/burning urination, or
• pink/bloody urine.
• severe itching, burning, rask, blistering, peeling, or dryness of the skin,
• cough,
• shortness of breath,
• pinpoint purple or red spots under your skin,
• flu symptoms, or
• weight loss.

Evista (raloxifene hydrochloride) is an estrogen agonist/antagonist used to treat or prevent osteoporosis in postmenopausal women. Evista is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are otherwise at risk of invasive breast cancer.

Prolia (denosumab) is a monoclonal antibody used to treat bone loss (osteoporosis) in women who are at high risk for bone fracture after menopause.

Evista may interact with cholestyramine, blood thinners, diazepam, diazoxide, birth control pills or hormone replacement therapy.

Prolia may interact with steroids or cancer medicine, cyclosporine, sirolimus, tacrolimus, basiliximab, muromonab-CD3, mycophenolate mofetil, azathioprine, leflunomide, or etanercept.

The recommended dosage is one 60 mg Evista tablet daily, taken any time of day without regard to meals.

The dose of Prolia is one 150 mg tablet taken once monthly on the same date each month.