Evoclin Side Effects Center

Last updated on RxList: 1/17/2023
Evoclin Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Evoclin?

Evoclin (clindamycin phosphate) is an antibiotic used to treat severe acne. Evoclin is available in generic form.

What Are Side Effects of Evoclin?

Evoclin may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • severe redness,
  • itching,
  • dryness of treated skin areas,
  • severe stomach pain, and
  • diarrhea that is watery or bloody (even if it occurs months after your last dose)

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Evoclin include:

  • application site reactions (redness, itching, dryness of treated skin areas, burning, irritation, or pain)
  • hives
  • abdominal pain or discomfort
  • hypersensitivity
  • rash
  • nausea
  • scaly skin
  • dizziness

Tell your doctor if you experience serious side effects of Evoclin including:

  • severe redness
  • itching
  • dryness of treated skin areas
  • watery or bloody diarrhea

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Evoclin

It is recommended to apply Evoclin to the affected areas once daily after skin is washed and dried.

What Drugs, Substances, or Supplements Interact with Evoclin?

Evoclin may interact with erythromycin. Discontinue use of Evoclin and contact your doctor immediately if you experience severe or bloody diarrhea, or colitis. Avoid contact of Evoclin with eyes, mouth, lips, other mucous membranes, and broken skin. If contact occurs rinse thoroughly with water.

Evoclin During Pregnancy or Breastfeeding

Caution should be taken if you are pregnant or breastfeeding while using Evoclin.

Additional Information

Our Evoclin (clindamycin phosphate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Evoclin Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using clindamycin topical and call your doctor at once if you have:

  • severe redness, itching, or dryness of treated skin areas; or
  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose).

Common side effects may include:

  • burning, itching, dryness, peeling or redness of treated skin; or
  • oily skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Acne is the result of an allergy. See Answer
Evoclin Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

A total of 439 subjects with mild to moderate acne vulgaris were treated once daily for 12 weeks with EVOCLIN Foam.

The incidence of adverse reactions occurring in ≥1% of the subjects in clinical trials comparing EVOCLIN Foam and its vehicle is presented in Table 1.

Table 1: Adverse Reactions Occurring in ≥1% of Subjects

Adverse Reactions Number (%) of Subjects
N = 439
Vehicle Foam
N = 154
Headache 12 (3%) 1 (1%)
Application site burning 27 (6%) 14 (9%)
Application site pruritus 5 (1%) 5 (3%)
Application site dryness 4 (1%) 5 (3%)
Application site reaction, not otherwise specified 3 (1%) 4 (3%)

In a contact sensitization study, none of the 203 subjects developed evidence of allergic contact sensitization to EVOCLIN Foam.

Postmarketing Experience

The following adverse reactions have been identified during post approval use of EVOCLIN Foam: application site pain, application site erythema, diarrhea, urticaria, abdominal pain, hypersensitivity, rash, abdominal discomfort, nausea, seborrhea, application site rash, dizziness, pain of skin, colitis (including pseudomembranous colitis), and hemorrhagic diarrhea. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Abdominal pain and gastrointestinal disturbances, as well as gram-negative folliculitis, have also been reported in association with the use of topical formulations of clindamycin. Orally and parenterally administered clindamycin have been associated with severe colitis, which may end fatally.

Read the entire FDA prescribing information for Evoclin (Clindamycin Phosphate)

© Evoclin Patient Information is supplied by Cerner Multum, Inc. and Evoclin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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