Exservan vs. Rilutek

Are Exservan and Rilutek the Same Thing?

Exservan (riluzole) and Rilutek (riluzole) are benzothiazole class drugs used to treat amyotrophic lateral sclerosis (ALS).

Side effects of Exservan and Rilutek that are similar include oral numbness, weakness/lethargy, nausea, vomiting, decreased lung function, stomach/abdominal pain, and dizziness.

Side effects of Exservan that are different from Rilutek include high blood pressure (hypertension), joint pain, dry mouth, insomnia, and itching.

Side effects of Rilutek that are different from Exservan include drowsiness, spinning sensation, diarrhea, constipation, muscle stiffness, headache, lightheadedness, tiredness, loss of appetite, and runny nose.

Both Exservan and Rilutek may interact with methyldopa, birth control pills or other hormones, allopurinol, and sulfasalazine.

Exservan may also interact with ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, thiabendazole, vemurafenib, zileuton, and CYP1A2 inducers.

Rilutek may also interact with acetaminophen, amitriptyline, auranofin, cancer medications, omeprazole, theophylline, tuberculosis medications, methotrexate, ACE inhibitors, antibiotics, antifungals, cholesterol medications, HIV/AIDS medications, nonsteroidal anti-inflammatory drugs (NSAIDs), and seizure medications.

What Are Possible Side Effects of Exservan?

Side effects of Exservan include:

  • ciprofloxacin,
  • enoxacin,
  • fluvoxamine,
  • methoxsalen,
  • mexiletine,
  • oral contraceptives,
  • thiabendazole,
  • vemurafenib,
  • zileuton,
  • CYP1A2 inducers,
  • allopurinol,
  • methyldopa, and
  • sulfasalazine

What Are Possible Side Effects of Rilutek?

Common side effects of Rilutek include:

  • weakness,
  • drowsiness,
  • nausea,
  • stomach pain,
  • dizziness,
  • spinning sensation,
  • decreased lung function,
  • diarrhea,
  • constipation,
  • muscle stiffness,
  • numbness or tingly feeling in or around your mouth,
  • headache,
  • lightheadedness,
  • tiredness,
  • vomiting,
  • loss of appetite, or
  • runny nose.

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What Is Exservan?

Exservan (riluzole) is a benzothiazole class drug used to treat amyotrophic lateral sclerosis (ALS).

What Is Rilutek?

Rilutek (riluzole) is a benzothiazole drug indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS). Rilutek is available as a generic. Rilutek extends survival and/or time to tracheostomy.

What Drugs Interact With Exservan?

Exservan may interact with other medicines such as:

  • ciprofloxacin,
  • enoxacin,
  • fluvoxamine,
  • methoxsalen,
  • mexiletine,
  • oral contraceptives,
  • thiabendazole,
  • vemurafenib,
  • zileuton,
  • CYP1A2 inducers,
  • allopurinol,
  • methyldopa, and
  • sulfasalazine

Tell your doctor all medications and supplements you use and all vaccines you recently received.

What Drugs Interact With Rilutek?

Rilutek may interact with acetaminophen, allopurinol, amitriptyline, auranofin, cancer medications, methyldopa, omeprazole, sulfasalazine, theophylline, tuberculosis medications, birth control pills or other hormones, methotrexate, ACE inhibitors, antibiotics, antifungals, cholesterol medications, HIV/AIDS medications, nonsteroidal anti-inflammatory drugs (NSAIDs), or seizure medications. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Rilutek; it is unknown if it will harm a fetus. It is unknown if Rilutek passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

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How Should Exservan Be Taken?

The recommended dosage of Exservan is 50 mg twice daily, taken at least 1 hour before or 2 hours after a meal.

How Should Rilutek Be Taken?

Rilutek is available as 50mg tablets; the dose is 50 mg every 12 hours.

Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

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If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
SOURCE:

FDA. Exservan Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2019/212640Orig1s000ltr.pdf

FDA. Rilutek Product Monograph.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020599s011s012lbl.pdf

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